Brain oscillations and connectivity in autism spectrum disorders (ASD):new approaches to methodology, measurement and modelling


Although atypical social behaviour remains a key characterisation of ASD, the presence ofsensory and perceptual abnormalities has been given a more central role in recentclassification changes. An understanding of the origins of such aberrations could thus prove afruitful focus for ASD research. Early neurocognitive models of ASD suggested that thestudy of high frequency activity in the brain as a measure of cortical connectivity mightprovide the key to understanding the neural correlates of sensory and perceptual deviations inASD. As our review shows, the findings from subsequent research have been inconsistent,with a lack of agreement about the nature of any high frequency disturbances in ASD brains.Based on the application of new techniques using more sophisticated measures of brainsynchronisation, direction of information flow, and invoking the coupling between high andlow frequency bands, we propose a framework which could reconcile apparently conflictingfindings in this area and would be consistent both with emerging neurocognitive models ofautism and with the heterogeneity of the condition.

Publication DOI:
Divisions: College of Health & Life Sciences > School of Psychology
College of Health & Life Sciences > Clinical and Systems Neuroscience
College of Health & Life Sciences > School of Optometry > Centre for Vision and Hearing Research
College of Health & Life Sciences
College of Health & Life Sciences > Aston Institute of Health & Neurodevelopment (AIHN)
Additional Information: © 2016, Elsevier. Licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International
Uncontrolled Keywords: Autism,Brain connectivity,Brain oscillations,Gamma,Predictive coding,Neuropsychology and Physiological Psychology,Cognitive Neuroscience,Behavioral Neuroscience
Publication ISSN: 1873-7528
Last Modified: 01 Apr 2024 07:16
Date Deposited: 20 Oct 2016 08:40
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Related URLs: http://www.scop ... tnerID=8YFLogxK (Scopus URL)
PURE Output Type: Article
Published Date: 2016-12
Published Online Date: 2016-10-05
Accepted Date: 2016-10-04
Submitted Date: 2016-06-10
Authors: Kessler, K. (ORCID Profile 0000-0001-7307-9539)
Seymour, R.A. (ORCID Profile 0000-0001-8600-8123)
Rippon, G. (ORCID Profile 0000-0002-3574-745X)

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