Microparticle surface layering through dry coating:impact of moisture content and process parameters on the properties of orally disintegrating tablets


OBJECTIVES: The aim of this study was to investigate the influence of process parameters during dry coating on particle and dosage form properties upon varying the surface adsorbed moisture of microcrystalline cellulose (MCC), a model filler/binder for orally disintegrating tablets (ODTs). METHODS: The moisture content of MCC was optimised using the spray water method and analysed using thermogravimetric analysis. Microproperty/macroproperty assessment was investigated using atomic force microscopy, nano-indentation, scanning electron microscopy, tablet hardness and disintegration testing. KEY FINDINGS: The results showed that MCC demonstrated its best flowability at a moisture content of 11.2% w/w when compared to control, comprising of 3.9% w/w moisture. The use of the composite powder coating process (without air) resulted in up to 80% increase in tablet hardness, when compared to the control. The study also demonstrated that surface adsorbed moisture can be displaced upon addition of excipients during dry processing circumventing the need for particle drying before tabletting. CONCLUSIONS: It was concluded that MCC with a moisture content of 11% w/w provides a good balance between powder flowability and favourable ODT characteristics.

Publication DOI: https://doi.org/10.1111/jphp.12623
Divisions: College of Health & Life Sciences > Aston Pharmacy School
College of Health & Life Sciences
College of Health & Life Sciences > Chronic and Communicable Conditions
Additional Information: This is the peer reviewed version of the following article: Alyami, H., Koner, J., Dahmash, E. Z., Bowen, J., Terry, D., & Mohammed, A. R. (2016). Microparticle surface layering through dry coating: impact of moisture content and process parameters on the properties of orally disintegrating tablets. Journal of Pharmacy and Pharmacology, Early view, which has been published in final form at http://dx.doi.org/10.1111/jphp.12623. This article may be used for non-commercial purposes in accordance with Wiley Terms and Conditions for Self-Archiving.
Uncontrolled Keywords: composite,disintegration,flowability,hardness,nano-indentation,Pharmacology,Pharmaceutical Science
Publication ISSN: 2042-7158
Last Modified: 30 Apr 2024 07:10
Date Deposited: 11 Oct 2016 07:40
Full Text Link: http://onlineli ... .12623/abstract
Related URLs: http://www.scop ... tnerID=8YFLogxK (Scopus URL)
PURE Output Type: Article
Published Date: 2017-07
Published Online Date: 2016-10-02
Accepted Date: 2016-07-26
Submitted Date: 2016-03-28
Authors: Alyami, Hamad
Koner, Jasdip
Dahmash, Eman Z.
Bowen, James
Terry, David (ORCID Profile 0000-0001-7599-0916)
Mohammed, Afzal R. (ORCID Profile 0000-0002-5212-3040)



Version: Accepted Version

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