Systemic inflammatory impact of periodontitis on acute coronary syndrome


Aim: A causative relationship between acute coronary syndrome (ACS) and periodontitis has yet to be defined. The aim of this study was to assess differences in levels of serum cytokines between individuals with or without ACS or periodontal comorbidity. Material and Methods: In a case–control study, individuals with ACS (78 individuals, 10.3% females) and matching healthy controls (78 individuals, 28.2% females) were included. Medical and dental examinations were performed to diagnose ACS and periodontitis. Serum levels of cytokines were assessed, using Luminex technology. Results: A diagnosis of periodontitis in the ACS and control group was diagnosed in 52.6% and 12.8% of the individuals, respectively. The unadjusted odds-ratio that individuals with ACS also had periodontitis was 7.5 (95% CI: 3.4, 16.8, p

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Divisions: College of Health & Life Sciences > Aston Pharmacy School
College of Health & Life Sciences
College of Health & Life Sciences > Chronic and Communicable Conditions
College of Health & Life Sciences > School of Biosciences > Cellular and Molecular Biomedicine
Additional Information: This is the peer reviewed version of the following article: Widén, C., Holmer, H., Coleman, M., Tudor, M., Ohlsson, O., Sättlin, S., ... Persson, G. R. (2016). Systemic inflammatory impact of periodontitis on acute coronary syndrome. Journal of Clinical Periodontology, 43(9), 713-719, which has been published in final form at This article may be used for non-commercial purposes in accordance with Wiley Terms and Conditions for Self-Archiving
Uncontrolled Keywords: cardiovascular disease,cytokines,hs-CRP,human,oral disease,serum,VEGF,Periodontics
Publication ISSN: 1600-051X
Last Modified: 25 Apr 2024 07:11
Date Deposited: 31 Aug 2016 08:35
Full Text Link: http://onlineli ... .12540/abstract
Related URLs: http://www.scop ... tnerID=8YFLogxK (Scopus URL)
PURE Output Type: Article
Published Date: 2016-09
Published Online Date: 2016-07-02
Accepted Date: 2016-02-27
Authors: Widén, Cecilia
Holmer, Helene
Coleman, Michael (ORCID Profile 0000-0002-5510-6852)
Tudor, Marian
Ohlsson, Ola
Sättlin, Susanna
Renvert, Stefan
Persson, Goesta Rutger



Version: Accepted Version

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