Wang, Zhipeng, Tan, Jiao, McConville, Christopher, Kannappan, Vinodh, Erebi Tawari, Patricia, Brown, James, Ding, Jin, Armesilla, Angel L., Irache, Juan M., Mei, Qi-Bing, Tan, Yuhuan, Liu, Ying, Jiang, Wenguo, Bian, Xiuwu and Wang, Weiguang (2017). Poly lactic-co-glycolic acid controlled delivery of Disulfiram to target liver cancer stem-like cells. Nanomedicine: Nanotechnology, Biology, and Medicine, 13 (2), pp. 641-657.
Abstract
Disulfiram (DS), an anti-alcoholism drug, shows very strong cytotoxicity in many cancer types. However its clinical application in cancer treatment is limited by the very short half-life in the bloodstream. In this study, we developed a poly lactic-co-glycolic acid (PLGA)-encapsulated DS protecting DS from the degradation in the bloodstream. The newly developed DS-PLGA was characterized. The DS-PLGA has very satisfactory encapsulation efficiency, drug-loading content and controlled release rate in vitro. PLGA encapsulation extended the half-life of DS from shorter than 2 minutes to 7 hours in serum. In combination with copper, DS-PLGA significantly inhibited the liver cancer stem cell population. CI-isobologram showed a remarkable synergistic cytotoxicity between DS-PLGA and 5-FU or Sorafenib. It also demonstrated very promising anticancer efficacy and antimetastatic effect in liver cancer mouse model. Both DS and PLGA are FDA approved products for clinical application. Our study may lead to repositioning of DS into liver cancer treatment.
Publication DOI: | https://doi.org/10.1016/j.nano.2016.08.001 |
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Divisions: | College of Health & Life Sciences > School of Biosciences College of Health & Life Sciences College of Health & Life Sciences > Chronic and Communicable Conditions College of Health & Life Sciences > School of Biosciences > Cell & Tissue Biomedical Research |
Additional Information: | © 2016 The Authors. Published by Elsevier Inc. This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/ licenses/by-nc-nd/4.0/). |
Uncontrolled Keywords: | disulfiram,PLGA,liver cancer,cancer stem cells,drug repositioning,nano-technology,drug delivery,Medicine (miscellaneous),Bioengineering,Biomedical Engineering,Molecular Medicine,General Materials Science,Pharmaceutical Science |
Publication ISSN: | 1549-9634 |
Last Modified: | 30 Sep 2024 10:55 |
Date Deposited: | 18 Aug 2016 07:35 |
Full Text Link: | |
Related URLs: |
http://www.scop ... tnerID=8YFLogxK
(Scopus URL) |
PURE Output Type: | Article |
Published Date: | 2017-02 |
Published Online Date: | 2016-08-10 |
Accepted Date: | 2016-08-01 |
Submitted Date: | 2016-03-29 |
Authors: |
Wang, Zhipeng
Tan, Jiao McConville, Christopher Kannappan, Vinodh Erebi Tawari, Patricia Brown, James ( 0000-0002-3504-7373) Ding, Jin Armesilla, Angel L. Irache, Juan M. Mei, Qi-Bing Tan, Yuhuan Liu, Ying Jiang, Wenguo Bian, Xiuwu Wang, Weiguang |
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