Modulation of cholesterol in midlife affords cognitive advantage during ageing - a role for altered redox balance


General practitioners, geriatricians, neurologists and health care professionals all over the world will be facing by 2040 the diagnostic, therapeutic and socioeconomic challenges of over 80 million people with dementia. Dementia is one of the most common diseases in the elderly which drastically affects daily life and everyday personal activities, is often associated with behavioural symptoms, personality change and numerous clinical complications and increases the risk for urinary incontinence, hip fracture, and - most markedly - the dependence on nursing care. The costs of care for patients with dementia are therefore immense. Serum cholesterol levels above 6.5 mmol/L are known to be associated with an increased RR of 1.5 and 2.1 to develop Alzheimeŕs disease, the most common form of dementia, and a reduction of serum cholesterol in midlife is associated with a lowered dementia risk. The aim of this work is to critically discuss some of the main results reported recently in the literature in this respect and to provide the pathophysiological rationale for the control of dyslipidemia in the prevention of dementia onset and progression.

Divisions: College of Health & Life Sciences
College of Health & Life Sciences > Chronic and Communicable Conditions
Uncontrolled Keywords: ageing,cholesterol,cognition,LDL,oxidation,Medicine(all),Biochemistry, Genetics and Molecular Biology(all)
Publication ISSN: 1940-5901
Full Text Link: http://www.ijce ... m/1002004A.html
Related URLs: http://www.scop ... tnerID=8YFLogxK (Scopus URL)
PURE Output Type: Article
Published Date: 2010-08-18
Published Online Date: 2010-04-20
Accepted Date: 2010-04-10
Submitted Date: 2010-01-08
Authors: Polidori, M. Cristina
Pientka, Ludger
Nelles, Gereon
Griffiths, Helen R. (ORCID Profile 0000-0002-2666-2147)



Version: Published Version

License: Creative Commons Attribution Non-commercial

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