Characterization of Grewia gum, a potential pharmaceutical excipient


Grewia gum was extracted from the inner stem bark of Grewia mollis and characterized by several techniques such as gas chromatography (GC), gel permeation chromatography (GPC), scanning electron microscopy (SEM), differential scanning calorimetry (DSC) and thermogravimetric analysis of the extracted sample. Spectroscopic techniques such as x-ray photoelectron spectroscopy (XPS), fourier-transformed infrared (FT-IR), solid-state nuclear magnetic resonance (NMR), and 1H and 13C NMR techniques were also used to characterize the gum. The results showed that grewia gum is a typically amorphous polysaccharide gum containing glucose, rhamnose, galactose, arabinose and xylose as neutral sugars. It has an average molecular weight of 5925 kDa expressed as the pullulan equivalent. The gum slowly hydrated in water, dispersing and swelling to form a highly viscous dispersion exhibiting pseudoplastic flow behaviour. The polysaccharide gum is thermally stable and may have application as stabilizer or suspending agent in foods, cosmetics and in pharmaceuticals. It may have application as a binder or sustained-release polymer matrix in tablets or granulations.

Divisions: College of Health & Life Sciences > Aston Pharmacy School
College of Health & Life Sciences
Additional Information: The Journal of Excipients and Food Chemicals is published under a Creative Commons Attribution-Non Commercial-No DerivativeWorks 4.0 International License. A v/ SPARC Europe Certified Journal.
Uncontrolled Keywords: binder,excipient,extraction,grewia gum,polysaccharide,suspending agent,sustained release,Food Science,Pharmaceutical Science
Publication ISSN: 2150-2668
Last Modified: 30 May 2024 07:10
Date Deposited: 26 Jul 2016 12:45
Full Text Link: http://ojs.abo. ... article/view/12
Related URLs: http://www.scop ... tnerID=8YFLogxK (Scopus URL)
PURE Output Type: Article
Published Date: 2010-12
Accepted Date: 2010-05-12
Submitted Date: 2010-04-07
Authors: Nep, Elijah I.
Conway, Barbara R.

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