Measurement and correlation of the solubility of telmisartan (form A) in nine different solvents from 277.85 to 338.35 K


The solubility of telmisartan (form A) in nine organic solvents (chloroform, dichloromethane, ethanol, toluene, benzene, 2-propanol, ethyl acetate, methanol and acetone) was determined by a laser monitoring technique at temperatures from 277.85 to 338.35 K. The solubility of telmisartan (form A) in all of the nine solvents increased with temperature as did the rates at which the solubility increased except in chloroform and dichloromethane. The mole fraction solubility in chloroform is higher than that in dichloromethane, which are both one order of magnitude higher than those in the other seven solvents at the experimental temperatures. The solubility data were correlated with the modified Apelblat equation and λh equations. The results show that the λh equation is in better agreement with the experimental data than the Apelblat equation. The relative root mean square deviations (σ) of the λh equation are in the range from 0.004 to 0.45 %. The dissolution enthalpies, entropies and Gibbs energies of telmisartan in these solvents were estimated by the Van’t Hoff equation and the Gibbs equation. The melting point and the fusion enthalpy of telmisartan were determined by differential scanning calorimetry.

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Divisions: College of Engineering & Physical Sciences > School of Infrastructure and Sustainable Engineering > Chemical Engineering & Applied Chemistry
College of Engineering & Physical Sciences > Energy and Bioproducts Research Institute (EBRI)
Additional Information: The final publication is available at Springer via
Uncontrolled Keywords: telmisartan,solubility,apelblat equation,λh equation,olution thermodynamic properties
Publication ISSN: 1572-8927
Last Modified: 11 Apr 2024 07:10
Date Deposited: 28 Jun 2016 08:25
Full Text Link: http://link.spr ... 0953-016-0484-8
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PURE Output Type: Article
Published Date: 2016-06-06
Accepted Date: 2016-05-06
Submitted Date: 2015-05-31
Authors: Liu, Wenju
Guo, Yajun
Chen, Jiaxing
Yu, Xi (ORCID Profile 0000-0003-3574-6032)



Version: Published Version

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