Wearable sensors in Huntington disease:a pilot study


Background: The Unified Huntington’s Disease Rating Scale (UHDRS) is the principal means of assessing motor impairment in Huntington disease but is subjective and generally limited to in-clinic assessments. Objective: To evaluate the feasibility and ability of wearable sensors to measure motor impairment in individuals with Huntington disease in the clinic and at home. Methods: Participants with Huntington disease and controls were asked to wear five accelerometer-based sensors attached to the chest and each limb for standardized, in-clinic assessments and for one day at home. A secondchest sensor was worn for six additional days at home. Gait measures were compared between controls, participants with Huntington disease, and participants with Huntington disease grouped by UHDRS total motor score using Cohen’s d values. Results: Fifteen individuals with Huntington disease and five controls completed the study. Sensor data were successfully captured from 18 of the 20 participants at home. In the clinic, the standard deviation of step time (timebetween consecutive steps) was increased in Huntington disease (p<0.0001; Cohen’s d=2.61) compared to controls. At home with additional observations, significant differences were observed in seven additional gait measures. The gait of individuals with higher total motor scores (50 or more) differed significantly from those with lower total motor scores (below 50) on multiple measures at home. Conclusions: In this pilot study, the use of wearable sensors in clinic and at home was feasible and demonstrated gait differences between controls, participants with Huntington disease, and participants with Huntington diseasegrouped by motor impairment.

Publication DOI: https://doi.org/10.3233/JHD-160197
Divisions: College of Engineering & Physical Sciences > Systems analytics research institute (SARI)
Additional Information: The final publication is available at IOS Press through http://dx.doi.org/10.3233/JHD-160197
Uncontrolled Keywords: Huntington disease,remote sensing technology,clinical study,movement,gait,chorea,ambulatory monitoring
Publication ISSN: 1879-6400
Last Modified: 29 Apr 2024 07:14
Date Deposited: 25 May 2016 13:13
Full Text Link: http://content. ... sease/jhd160197
http://www.medr ... 3233/JHD-160197
Related URLs: http://www.scop ... tnerID=8YFLogxK (Scopus URL)
PURE Output Type: Article
Published Date: 2016-07-01
Published Online Date: 2016-06-18
Accepted Date: 2016-05-23
Authors: Andrzejewski, Kelly L.
Dowling, Ariel V.
Stamler, David
Felong, Timothy J.
Harris, Denzil A.
Wong, Cynthia
Cai, Hang
Reilmann, Ralf
Little, Max A. (ORCID Profile 0000-0002-1507-3822)
Gwin, Joseph T.
Biglan, Kevin M.
Dorsey, E. Ray



Version: Accepted Version

License: ["licenses_description_unspecified" not defined]

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