Neuropsychiatric manifestations in inflammatory neuropathies:a systematic review


We conducted a systematic literature review on psychological and behavioral comorbidities in patients with inflammatory neuropathies. In Guillain-Barré syndrome (GBS), psychotic symptoms are reported during early stages in 30% of patients. Typical associations include mechanical ventilation, autonomic dysfunction, inability to communicate, and severe weakness. Anxiety and depression are frequent comorbidities. Anxiety may increase post-hospital admissions and be a predictor of mechanical ventilation. Post-traumatic stress disorder may affect up to 20% of ventilated patients. Sleep disturbances are common in early-stage GBS, affecting up to 50% of patients. In chronic inflammatory demyelinating polyradiculoneuropathy, memory and quality of sleep may be impaired. An independent link between depression and pre-treatment upper limb disability and ascites was reported in POEMS (Polyneuropathy, Organomegaly, Endocrinopathy, M-protein, Skin) syndrome, with an association with early death. Hematological treatment of POEMS appears effective on depression. Published literature on psychological/behavioral manifestations in inflammatory neuropathies remains scarce, and further research is needed. This article is protected by copyright. All rights reserved.

Publication DOI:
Divisions: College of Health & Life Sciences > School of Psychology
College of Health & Life Sciences
College of Health & Life Sciences > Clinical and Systems Neuroscience
College of Health & Life Sciences > Aston Institute of Health & Neurodevelopment (AIHN)
Additional Information: This is the peer reviewed version of the following article: Rajabally, Y. A., Seri, S., & Cavanna, A. E. (2016). Neuropsychiatric manifestations in inflammatory neuropathies: a systematic review. Muscle & nerve, Early view, which has been published in final form at This article may be used for non-commercial purposes in accordance with Wiley Terms and Conditions for Self-Archiving.
Uncontrolled Keywords: chronic inflammatory demyelinating polyneuropathy,Guillain–Barré syndrome,inflammatory,neuropsychiatric,neuropathy,POEMS syndrome
Publication ISSN: 1097-4598
Full Text Link: http://onlineli ... .25112/abstract
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PURE Output Type: Review article
Published Date: 2016-07
Published Online Date: 2016-05-10
Accepted Date: 2016-03-21
Authors: Rajabally, Yusuf A.
Seri, Stefano (ORCID Profile 0000-0002-9247-8102)
Cavanna, Andrea E.



Version: Accepted Version

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