Changes in autofluorescence based organoid model of muscle invasive urinary bladder cancer


Muscle invasive urinary bladder cancer is one of the most lethal cancers and its detection at the time of transurethral resection remains limited and diagnostic methods are urgently needed. We have developed a muscle invasive transitional cell carcinoma (TCC) model of the bladder using porcine bladder scaffold and the human bladder cancer cell line 5637. The progression of implanted cancer cells to muscle invasion can be monitored by measuring changes in the spectrum of endogenous fluorophores such as reduced nicotinamide dinucleotide (NADH) and flavins. We believe this could act as a useful tool for the study of fluorescence dynamics of developing muscle invasive bladder cancer in patients.

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Divisions: College of Engineering & Physical Sciences
Additional Information: Published by The Optical Society under the terms of the Creative Commons Attribution 4.0 License . Further distribution of this work must maintain attribution to the author(s) and the published article’s title, journal citation, and DOI. Funding: EU FP7 (project ABLADE grant 324370); studentship from NHS and EPSRC (grant number EP/K503010/1); state task of the Ministry of Education and Science, Russian Federation, for the State University – Education-Science-Production Complex (basic part, No 310)
Uncontrolled Keywords: Atomic and Molecular Physics, and Optics,Biotechnology
Publication ISSN: 2156-7085
Last Modified: 18 Mar 2024 08:16
Date Deposited: 18 May 2016 13:15
Full Text Link: https://www.osa ... ri=boe-7-4-1193
Related URLs: http://www.scop ... tnerID=8YFLogxK (Scopus URL)
PURE Output Type: Article
Published Date: 2016-03-07
Published Online Date: 2016-03-01
Accepted Date: 2016-02-13
Submitted Date: 2015-12-10
Authors: Palmer, Scott
Litvinova, Karina (ORCID Profile 0000-0003-1110-8589)
Dunaev, Andrey
Fleming, Stewart
McGloin, David
Nabi, Ghulam



Version: Published Version

License: Creative Commons Attribution

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