Grewia gum 2:mucoadhesive properties of compacts and gels


Purpose: To compare the mucoadhesive performance of grewia polysaccharide gum with those of guar gum, carboxymethylcellulose, hydroxypropyl methylcellulose and carbopol 971P. Methods: Grewia polysaccharide gum compacts or gels as well as those of guar gum, carboxymethylcellulose, hydroxypropyl methylcellulose or carbopol 971P were prepared. Texturometric and tensile analysis of the polymer gels and compacts were carried out using a software-controlled penetrometre, TA.XTPlus texture analyzer. The polymer gels were evaluated for hardness, stickiness, work of cohesion and work of adhesion. Furthermore, the detachment force of the polymer compacts from a mucin substrate was evaluated. Results: The work of adhesion of guar gels was significantly greater than that of grewia gels (p < 0.001) but the latter showed a significantly greater work of adhesion than carboxymethylcellulose gels (p < 0.05) and hydroxypropyl methylcellulose gels (p < 0.001). However, the work of cohesion for grewia/mucin gel mixture was significantly greater (p < 0.001) than those of carboxymethylcellulose/mucin, hydroxypropyl methylcellulose/mucin and carbopol 971P/mucin gel blends. The difference between the mucoadhesive performance of grewia compacts and those of hydroxypropyl methylcellulose and carbopol 971P compacts was insignificant (p > 0.05). Conclusion: Grewia polysaccharide gum demonstrated good mucoadhesive properties, comparable to those of carbopol 971P, carboxymethylcellulose, guar gum and hydroxypropyl methylcellulose, and therefore, should be suitable for the formulation of retentive drug delivery devices.

Publication DOI:
Divisions: College of Health & Life Sciences > Aston Pharmacy School
Additional Information: Creative Commons Attribution License ( © Pharmacotherapy Group
Uncontrolled Keywords: Grewia polysaccharide gum,mucoadhesive performance,texture analyzer,work of cohesion/adhesion,Pharmaceutical Science,Pharmacology (medical)
Publication ISSN: 1596-9827
Last Modified: 26 Apr 2024 17:28
Date Deposited: 14 Mar 2016 15:10
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Related URLs: http://www.scop ... tnerID=8YFLogxK (Scopus URL)
http://www.tjpr ... 2011_10_4_4.php (Publisher URL)
PURE Output Type: Article
Published Date: 2011-08
Accepted Date: 2011-06-10
Submitted Date: 2010-10-30
Authors: Nep, Elijah I.
Conway, Barbara R.



Version: Published Version

License: Creative Commons Attribution

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