The application of fixed hydrophobic patterns for confinement of aqueous solutions in proteomic microarrays


A protein microarray hybridisation system has been implemented by employing patterned hydrophobic thin films on hydrophilic substrates as a means of confinement for aqueous samples. This approach has the ability to handle, and keep separate, small sample volumes of just a few microlitres. In addition, the system is more straightforward to use than the existing multi-well gasket solution. The paper describes the fabrication method and the system is demonstrated for a model protein microarray assay.

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Divisions: College of Health & Life Sciences > Aston Pharmacy School
College of Health & Life Sciences
College of Health & Life Sciences > School of Biosciences > Cellular and Molecular Biomedicine
Additional Information: Copyright © 2011 American Institute of Physics. This article may be downloaded for personal use only. Any other use requires prior permission of the author and the American Institute of Physics. The following article appeared in Appl. Phys. Lett. 99, 073703 (2011); and may be found at
Uncontrolled Keywords: Physics and Astronomy (miscellaneous)
Publication ISSN: 1077-3118
Last Modified: 05 Jan 2024 08:06
Date Deposited: 14 Mar 2016 14:15
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Related URLs: http://www.scop ... tnerID=8YFLogxK (Scopus URL)
http://scitatio ... .1063/1.3626037 (Publisher URL)
PURE Output Type: Article
Published Date: 2011-08-15
Authors: Li, Y.
McKenna, E.O.
Parkes, W.
Pitt, A.R. (ORCID Profile 0000-0003-3619-6503)
Walton, A.J.



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