IUPHAR-DB:the IUPHAR database of G protein-coupled receptors and ion channels


The IUPHAR database (IUPHAR-DB) integrates peer-reviewed pharmacological, chemical, genetic, functional and anatomical information on the 354 nonsensory G protein-coupled receptors (GPCRs), 71 ligand-gated ion channel subunits and 141 voltage-gated-like ion channel subunits encoded by the human, rat and mouse genomes. These genes represent the targets of approximately one-third of currently approved drugs and are a major focus of drug discovery and development programs in the pharmaceutical industry. IUPHAR-DB provides a comprehensive description of the genes and their functions, with information on protein structure and interactions, ligands, expression patterns, signaling mechanisms, functional assays and biologically important receptor variants (e.g. single nucleotide polymorphisms and splice variants). In addition, the phenotypes resulting from altered gene expression (e.g. in genetically altered animals or in human genetic disorders) are described. The content of the database is peer reviewed by members of the International Union of Basic and Clinical Pharmacology Committee on Receptor Nomenclature and Drug Classification (NC-IUPHAR); the data are provided through manual curation of the primary literature by a network of over 60 subcommittees of NC-IUPHAR. Links to other bioinformatics resources, such as NCBI, Uniprot, HGNC and the rat and mouse genome databases are provided. IUPHAR-DB is freely available at http://www.iuphar-db.org.

Publication DOI: https://doi.org/10.1093/nar/gkn728
Divisions: College of Health & Life Sciences
Additional Information: © 2008 The Author(s) This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/ by-nc/2.0/uk/) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.
Uncontrolled Keywords: Genetics
Publication ISSN: 1362-4962
Last Modified: 08 May 2024 07:11
Date Deposited: 10 Feb 2016 14:55
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Related URLs: http://www.scop ... tnerID=8YFLogxK (Scopus URL)
https://academi ... _1/D680/1007740 (Publisher URL)
PURE Output Type: Article
Published Date: 2009-01-01
Published Online Date: 2008-10-23
Authors: Harmar, Anthony J.
Hills, Rebecca A.
Rosser, Edward M.
Jones, Martin
Buneman, O. Peter
Dunbar, Donald R.
Greenhill, Stuart D. (ORCID Profile 0000-0002-5038-5258)
Hale, Valerie A.
Sharman, Joanna L.
Bonner, Tom I.
Catterall, William A.
Davenport, Anthony P.
Delagrange, Philippe
Dollery, Colin L.
Foord, Steven M.
Gutman, George A.
Laudet, Vincent
Neubig, Richard R.
Ohlstein, Eliot H.
Olsen, Richard W.
Peters, John
Pin, Jean-Philippe
Ruffolo, Robert R.
Searls, David B.
Wright, Mathew W.
Spedding, Michael


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