Histaminergic modulation in Tourette syndrome


Introduction: Tourette syndrome is a neurodevelopmental disorder characterized by multiple motor tics and at least one vocal/phonic tic. Clinical phenotypes show a wide variability, often incorporating behavioral symptoms. The exact pathophysiology of Tourette syndrome is unknown, however genetic vulnerability and alterations in dopaminergic neurotransmission have consistently been reported. Other biochemical pathways, including histaminergic neurotransmission, are likely to be involved but have received relatively little attention until recently. Areas covered: We conducted a systematic literature review focusing on the role of histaminergic neurotransmission and its pharmacological modulation in Tourette syndrome. We identified a number of relevant original studies published over the last five years, mainly focusing on genetic aspects. Expert opinion: There is converging evidence from recent studies supporting the hypothesis that histaminergic neurotransmission may play a role in the pathophysiology of Tourette syndrome. Most studies focused on the role of the histidine decarboxylase gene and the potential usefulness of histidine decarboxylase knockout mice as an experimental model for studying neurochemical function in Tourette syndrome. There have been no large scale studies assessing the use of histaminergic medications in the management of Tourette syndrome. This would be an important area for future research, with direct implications for the clinical management of selected phenotypes.

Publication DOI: https://doi.org/10.1517/21678707.2016.1128819
Divisions: College of Health & Life Sciences > School of Psychology
College of Health & Life Sciences > Clinical and Systems Neuroscience
College of Health & Life Sciences
College of Health & Life Sciences > Aston Institute of Health & Neurodevelopment (AIHN)
Additional Information: This is an Accepted Manuscript of an article published by Taylor & Francis in Expert Opinion on Orphan Drugs, on 5/1/16, available online: http://www.tandfonline.com/10.1517/21678707.2016.1128819
Uncontrolled Keywords: animal models,histamine,tics,Tourette syndrome,treatment,Pharmacology (medical),Health Policy,Pharmacology, Toxicology and Pharmaceutics (miscellaneous)
Publication ISSN: 2167-8707
Full Text Link: http://www.tand ... 07.2016.1128819
Related URLs: http://www.scop ... tnerID=8YFLogxK (Scopus URL)
PURE Output Type: Review article
Published Date: 2016-01-05
Published Online Date: 2015-12-05
Accepted Date: 2015-12-03
Submitted Date: 2015-09-27
Authors: Cox, Joanna H.
Seri, Stefano (ORCID Profile 0000-0002-9247-8102)
Cavanna, Andrea E.



Version: Accepted Version

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