Mild cognitive decline. A position statement of the Cognitive Decline Group of the European Innovation Partnership for Active and Healthy Ageing (EIPAHA)


Introduction Mild cognitive impairment (MCI) is a term used to describe a level of decline in cognition which is seen as an intermediate stage between normal ageing and dementia, and which many consider to be a prodromal stage of neurodegeneration that may become dementia. That is, it is perceived as a high risk level of cognitive change. The increasing burden of dementia in our society, but also our increasing understanding of its risk factors and potential interventions, require diligent management of MCI in order to find strategies that produce effective prevention of dementia. Aim To update knowledge regarding mild cognitive impairment, and to bring together and appraise evidence about the main features of clinical interest: definitions, prevalence and stability, risk factors, screening, and management and intervention. Methods Literature review and consensus of expert opinion. Results and conclusion MCI describes a level of impairment in which deteriorating cognitive functions still allow for reasonable independent living, including some compensatory strategies. While there is evidence for some early risk factors, there is still a need to more precisely delineate and distinguish early manifestations of frank dementia from cognitive impairment that is less likely to progress to dementia, and furthermore to develop improved prospective evidence for positive response to intervention. An important limitation derives from the scarcity of studies that take MCI as an endpoint. Strategies for effective management suffer from the same limitation, since most studies have focused on dementia. Behavioural changes may represent the most cost-effective approach.

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Divisions: College of Health & Life Sciences > School of Psychology
College of Health & Life Sciences
College of Health & Life Sciences > Chronic and Communicable Conditions
College of Health & Life Sciences > Aston Medical School
Additional Information: © 2015, Elsevier. Licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International
Uncontrolled Keywords: cognition,cognitive frailty,mild cognitive decline,position statement,Obstetrics and Gynaecology,General Biochemistry,Genetics and Molecular Biology
Publication ISSN: 1873-4111
Last Modified: 12 Jul 2024 07:05
Date Deposited: 18 Jan 2016 14:10
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Related URLs: http://www.scop ... tnerID=8YFLogxK (Scopus URL)
PURE Output Type: Review article
Published Date: 2016-01
Published Online Date: 2015-10-22
Accepted Date: 2015-10-09
Submitted Date: 2015-09-23
Authors: Apostolo, Joao
Holland, Carol (ORCID Profile 0000-0002-1846-8897)
O'Connell, Matthew D.L.
Feeney, Joanne
Tabares-Seisdedos, Rafael
Tadros, George (ORCID Profile 0000-0001-5820-7643)
Campos, Elzbieta
Santos, Nadine
Robertson, Deirdre A.
Marcucci, Maura
Varela-Nieto, Isabel
Crespo-Facorro, Benedicto
Vieta, Eduard
Navarro-Pardo, Esperanza
Selva-Vera, Gabriel
Balanzá-Martínez, Vicent
Cano, Antonio

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