Designing liposomal adjuvants for the next generation of vaccines


Liposomes not only offer the ability to enhance drug delivery, but can effectively act as vaccine delivery systems and adjuvants. Their flexibility in size, charge, bilayer rigidity and composition allow for targeted antigen delivery via a range of administration routes. In the development of liposomal adjuvants, the type of immune response promoted has been linked to their physico-chemical characteristics, with the size and charge of the liposomal particles impacting on liposome biodistribution, exposure in the lymph nodes and recruitment of the innate immune system. The addition of immunostimulatory agents can further potentiate their immunogenic properties. Here, we outline the attributes that should be considered in the design and manufacture of liposomal adjuvants for the delivery of sub-unit and nucleic acid based vaccines.

Publication DOI:
Divisions: College of Health & Life Sciences > Aston Pharmacy School
College of Health & Life Sciences
College of Health & Life Sciences > Chronic and Communicable Conditions
College of Health & Life Sciences > School of Biosciences
College of Health & Life Sciences > School of Biosciences > Cellular and Molecular Biomedicine
College of Health & Life Sciences > School of Biosciences > Cell & Tissue Biomedical Research
Additional Information: © 2015, Elsevier. Licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International Funding: EPSRC, Aston University, Novartis and an Nc3R grant
Uncontrolled Keywords: liposomes,vaccines,adjuvants,antigens,delivery systems,microfluidics,QbD,MVA,Pharmaceutical Science
Publication ISSN: 1872-8294
Last Modified: 01 Mar 2024 08:12
Date Deposited: 26 Nov 2015 09:00
Full Text Link:
Related URLs: http://www.scop ... tnerID=8YFLogxK (Scopus URL)
PURE Output Type: Article
Published Date: 2016-04-01
Published Online Date: 2015-11-11
Accepted Date: 2015-11-05
Submitted Date: 2015-05-12
Authors: Perrie, Yvonne
Crofts, Fraser
Devitt, Andrew (ORCID Profile 0000-0002-4651-6761)
Griffiths, Helen R (ORCID Profile 0000-0002-2666-2147)
Kastner, Elisabeth
Nadella, Vinod

Export / Share Citation


Additional statistics for this record