Redox control of protein degradation


Intracellular proteolysis is critical to maintain timely degradation of altered proteins including oxidized proteins. This review attempts to summarize the most relevant findings about oxidant protein modification, as well as the impact of reactive oxygen species on the proteolytic systems that regulate cell response to an oxidant environment: the ubiquitin-proteasome system (UPS), autophagy and the unfolded protein response (UPR). In the presence of an oxidant environment, these systems are critical to ensure proteostasis and cell survival. An example of altered degradation of oxidized proteins in pathology is provided for neurodegenerative diseases. Future work will determine if protein oxidation is a valid target to combat proteinopathies.

Publication DOI:
Divisions: College of Health & Life Sciences
College of Health & Life Sciences > Chronic and Communicable Conditions
College of Health & Life Sciences > School of Psychology
College of Health & Life Sciences > School of Biosciences > Cell & Tissue Biomedical Research
Additional Information: © 2015 The Authors. Published by Elsevier B.V. This is an open access article under the CC BY license ( Funding: European Cooperation in Science and Technology (COSTAction BM1203/EU-ROS); and Kidney Research UK (PDF3/2014).
Uncontrolled Keywords: protein degradation,reactive oxygen species,Biochemistry,Organic Chemistry
Publication ISSN: 2213-2317
Last Modified: 06 May 2024 07:13
Date Deposited: 21 Oct 2015 11:15
Full Text Link:
Related URLs: http://www.scop ... tnerID=8YFLogxK (Scopus URL)
PURE Output Type: Article
Published Date: 2015-12
Published Online Date: 2015-09-09
Authors: Pajares, Marta
Jiménez-Moreno, Natalia
Dias, Irundika H.K. (ORCID Profile 0000-0002-6620-8221)
Debelec, Bilge
Vucetic, Milica
Fladmark, Kari E.
Basaga, Huveyda
Ribaric, Samo
Milisav, Irina
Cuadrado, Antonio



Version: Published Version

License: Creative Commons Attribution

Export / Share Citation


Additional statistics for this record