Premonitory urges and sensorimotor processing in Tourette syndrome


Most patients with Tourette syndrome report characteristic sensory experiences (premonitory urges) associated with the expression of tic symptoms. Despite the central role of these experiences to the clinical phenomenology of Tourette syndrome, little is known about their underlying brain processes. In the present article we present the results of a systematic literature review of the published studies addressing the pathophysiological mechanisms of premonitory urges. We identified some preliminary evidence for specific alterations in sensorimotor processing at both cortical and subcortical levels. A better insight into the brain correlates of premonitory urges could lead to the identification of new targets to treat the sensory initiators of tics in patients with Tourette syndrome.

Publication DOI:
Divisions: College of Health & Life Sciences > School of Psychology
College of Health & Life Sciences > Clinical and Systems Neuroscience
College of Health & Life Sciences > Aston Institute of Health & Neurodevelopment (AIHN)
College of Health & Life Sciences
Additional Information: Copyright © 2013 Hindawi Publishing Corporation. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
Uncontrolled Keywords: pathophysiology,premonitory urges,sensori-motor processing,tics,Tourette syndrome,Neuropsychology and Physiological Psychology,Clinical Neurology,Neurology
Publication ISSN: 1875-8584
Last Modified: 12 Apr 2024 07:11
Date Deposited: 07 Sep 2015 12:55
Full Text Link: http://www.hind ... 013/984836/abs/
Related URLs: http://www.scop ... tnerID=8YFLogxK (Scopus URL)
PURE Output Type: Article
Published Date: 2013-05-06
Authors: Rajagopal, Sangeerthana
Seri, Stefano (ORCID Profile 0000-0002-9247-8102)
Cavanna, Andrea Eugenio



Version: Published Version

License: Creative Commons Attribution

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