Does anticholinergics drug burden relate to global neuro-disability outcome measures and length of hospital stay?


Primary objective: To assess the relationship between disability, length of stay (LOS) and anticholinergic burden (ACB) with people following acquired brain or spinal cord injury. Research design: A retrospective case note review assessed total rehabilitation unit admission. Methods and procedures: Assessment of 52 consecutive patients with acquired brain/spinal injury and neuropathy in an in-patient neuro-rehabilitation unit of a UK university hospital. Data analysed included: Northwick Park Dependency Score (NPDS), Rehabilitation complexity Scale (RCS), Functional Independence Measure and Functional Assessment Measure FIM-FAM (UK version 2.2), LOS and ACB. Outcome was different in RCS, NPDS and FIM-FAM between admission and discharge. Main outcomes and results: A positive change was reported in ACB results in a positive change in NPDS, with no significant effect on FIM-FAM, either Motor or Cognitive, or on the RCS. Change in ACB correlated to the length of hospital stay (regression correlation = −6.64; SE = 3.89). There was a significant harmful impact of increase in ACB score during hospital stay, from low to high ACB on NPDS (OR = 9.65; 95% CI = 1.36–68.64) and FIM-FAM Total scores (OR = 0.03; 95% CI = 0.002–0.35). Conclusions: There was a statistically significant correlation of ACB and neuro-disability measures and LOS amongst this patient cohort.

Publication DOI:
Divisions: College of Health & Life Sciences
College of Health & Life Sciences > Aston Pharmacy School
College of Health & Life Sciences > Chronic and Communicable Conditions
Uncontrolled Keywords: adverse event,Anticholingeric,function,length of stay,rehabilitation unit,spinal cord,traumatic brain injury,Clinical Neurology,Arts and Humanities (miscellaneous),Developmental and Educational Psychology
Publication ISSN: 1362-301X
Last Modified: 29 Apr 2024 07:12
Date Deposited: 02 Sep 2015 08:10
Full Text Link: http://informah ... 52.2015.1060358
Related URLs: http://www.scop ... tnerID=8YFLogxK (Scopus URL)
PURE Output Type: Article
Published Date: 2015
Published Online Date: 2015-08-05
Authors: Sakel, M.
Boukouvalas, A.
Buono, R.
Moten, M.
Mirza, F.
Chan, W.-Y.
Maidment, I. (ORCID Profile 0000-0003-4152-9704)
Cross, J.
Smith, T.O.
Myint, P.K.
Fox, C.



Version: Accepted Version

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