Ageing effect on flicker-induced diameter changes in retinal microvessels of healthy individuals

Abstract

Purpose: To compare flicker-induced retinal vessel diameter changes in varying age groups with low cardiovascular risk. Methods: Retinal vascular reactivity to flicker light was assessed by means of dynamic retinal vessel analysis in 57 participants aged 19-30 years, 75 participants aged 31-50 years and 62 participants aged 51-70 years participants. Other assessments included carotid intima-media thickness (c-IMT), augmentation index (AIx), blood pressure profiles, blood lipid metabolism markers and Framingham risk scores (FRS). Results: Retinal arterial dilation amplitude (DA) and postflicker percentage constriction (MC%) were significantly decreased in the oldest group compared to the middle-aged (p = 0.028; p = 0.021) and youngest group (p = 0.003; p = 0.026). The arterial constriction slope (Slope<inf>AC</inf>) was also decreased in the oldest group compared to the youngest group (p = 0.027). On the venous side, MC% was decreased in the middle-aged and oldest groups in comparison with the youngest group (p = 0.015; p = 0.010, respectively). Additionally, men exhibited increased arterial DA (p = 0.007), and percentage dilation (MD%, p < 0.001) in comparison with women, but only in the youngest age group. Both AIx and c-IMT scores increased with age (both p < 0.001); however, no correlations were found between the observed differences in the measured retinal vascular function and systemic parameters. Conclusion: In individuals with low cardiovascular risk, there are age-related differences in flicker-induced retinal vessel diameter changes throughout the entire functional response curve for arteries and veins. Gender differences mainly affect the arterial dilatory phase and are only present in young individuals.

Publication DOI: https://doi.org/10.1111/aos.12786
Divisions: College of Health & Life Sciences > School of Optometry > Optometry
College of Engineering & Physical Sciences > School of Informatics and Digital Engineering > Computer Science
College of Health & Life Sciences > School of Optometry > Optometry & Vision Science Research Group (OVSRG)
College of Health & Life Sciences
College of Health & Life Sciences > School of Optometry > Vision, Hearing and Language
Additional Information: This is the peer reviewed version of the following article: Seshadri, S., Ekart, A., & Gherghel, D. (2016). Ageing effect on flicker-induced diameter changes in retinal microvessels of healthy individuals. Acta ophthalmologica, 94(1), e35-e42, which has been published in final form at http://dx.doi.org/10.1111/aos.12786. This article may be used for non-commercial purposes in accordance with Wiley Terms and Conditions for Self-Archiving.
Uncontrolled Keywords: ageing,cardiovascular risk,dynamic retinal vessel analysis,retina,vascular function,Ophthalmology
Publication ISSN: 1755-375X
Full Text Link:
Related URLs: http://www.scop ... tnerID=8YFLogxK (Scopus URL)
http://onlineli ... .12786/abstract (Publisher URL)
PURE Output Type: Article
Published Date: 2016-02
Published Online Date: 2015-07-06
Accepted Date: 2015-05-21
Submitted Date: 2015-03-04
Authors: Seshadri, Swathi
Ekart, Aniko (ORCID Profile 0000-0001-6967-5397)
Gherghel, Doina (ORCID Profile 0000-0001-9439-5573)

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