Real-time detection of DNA interactions with long-period fiber-grating-based biosensor


Using an optical biosensor based on a dual-peak long-period fiber grating, we have demonstrated the detection of interactions between biomolecules in real time. Silanization of the grating surface was successfully realized for the covalent immobilization of probe DNA, which was subsequently hybridized with the complementary target DNA sequence. It is interesting to note that the DNA biosensor was reusable after being stripped off the hybridized target DNA from the grating surface, demonstrating a function of multiple usability. © 2007 Optical Society of America.

Publication DOI:
Divisions: College of Engineering & Physical Sciences > Aston Institute of Photonics Technology (AIPT)
College of Health & Life Sciences > School of Biosciences
College of Health & Life Sciences
College of Health & Life Sciences > School of Biosciences > Cellular and Molecular Biomedicine
Additional Information: © 2007 Optical Society of America. This paper was published in Optics Letters and is made available as an electronic reprint with the permission of OSA. The paper can be found at the following URL on the OSA website: Systematic or multiple reproduction or distribution to multiple locations via electronic or other means is prohibited and is subject to penalties under law.
Uncontrolled Keywords: biosensing techniques,DNA,equipment design,ebium,interferometry,lasers,light,models, theoretical,oscillometry,semiconductors,time factors,Ytterbium,Atomic and Molecular Physics, and Optics
Publication ISSN: 1539-4794
Last Modified: 29 May 2024 07:08
Date Deposited: 17 Jun 2015 15:21
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Related URLs: http://www.scop ... tnerID=8YFLogxK (Scopus URL)
http://www.opti ... I=ol-32-17-2541 (Publisher URL)
PURE Output Type: Article
Published Date: 2007-08-20
Authors: Chen, Xianfeng
Zhang, Lin (ORCID Profile 0000-0002-1691-5577)
Zhou, Kaiming (ORCID Profile 0000-0002-6011-1912)
Davies, Edward
Sugden, Kate (ORCID Profile 0000-0001-6323-1082)
Bennion, Ian
Hughes, Marcus D.
Hine, Anna V. (ORCID Profile 0000-0003-4065-831X)



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