A simple and efficient procedure for Knoevenagel reaction promoted by imidazolium-based ionic liquids


Various room temperature ionic liquids (RTILs), notably, 1-methoxyethyl-3-methylimidazolium trifluoroacetate [MeOEtMIM]+[CF3COO]ˉ , have been used to promote the Knoevenagel condensation to afford substituted olefins. All reactions proceeded effectively in the absence of any other catalysts or co-solvents with good to excellent yields. This method is simple and applicable to reactions involving a wide range of aldehydes and ketones with methylene compounds. The ionic liquid can be recycled without noticeable reduction of its catalytic activity. A plausible reaction mechanism is proposed.

Publication DOI: https://doi.org/10.2174/1570179412666150505185134
Divisions: College of Health & Life Sciences > Aston Pharmacy School
College of Health & Life Sciences
College of Health & Life Sciences > School of Biosciences > Cell & Tissue Biomedical Research
Additional Information: The published manuscript is available at EurekaSelect via http://www.eurekaselect.com/openurl/content.php?genre=article&doi=10.2174/1570179412666150505185134
Uncontrolled Keywords: Carbonyl compounds,Catalysis,Ionic liquids,Knoevenagel condensation,Olefins,Organic Chemistry,Biochemistry
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Related URLs: http://www.scop ... tnerID=8YFLogxK (Scopus URL)
http://www.eure ... /131017/article (Publisher URL)
PURE Output Type: Article
Published Date: 2016
Accepted Date: 2015-04-28
Submitted Date: 2015-01-14
Authors: Hu, Xiaomei
Ngwa, Conelius
Zheng, Qinguo (ORCID Profile 0000-0001-6351-4082)



Version: Accepted Version

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