Antipyretic, analgesic and anti-oxidative activities of Aquilaria crassna leaves extract in rodents

Abstract

In Thailand, the leaves of Aquilaria crassna have been used traditionally for the treatments of various disorders, but without any scientific analysis. In this study, the antipyretic, analgesic, anti-inflammatory and anti-oxidative properties of A. crassna leaves extract were investigated at a wide dose range in rodents. Experimental animals were treated orally with an aqueous extract of Aquilaria crassna leaves (ACE). They were tested for antipyretic (Baker′s yeast-induced fever in rats), analgesic (hot plate test in mice) and anti-inflammatory (carrageenan-induced paw edema in rats) activities. An anti-oxidative effect of ACE was evaluated by using the DPPH anti-oxidant assay. The results showed that, after 5 hours of yeast injection, 400 and 800 mg/kg ACE significantly reduced the rectal temperature of rats. Mice were found significantly less sensitive to heat at an oral dose of 800 mg/kg ACE, after 60 and 90 min. No anti-inflammatory activity of ACE at an 800 mg/kg dose could be observed in the rat paw assay. An anti-oxidative activity of ACE was observed with an IC 50 value of 47.18 g/ ml. No behavioral or movement change could be observed in mice after oral administration of ACE (800 or 8,000 mg/kg) for seven consecutive days. Interestingly, from the second day of treatment, animals had a significant lower body weight at the 8,000 mg/kg dose of ACE compared to the control. No toxicity was identified and the results of this study state clearly that Aquilaria crassna leaves extracts possess antipyretic, analgesic and anti-oxidative properties without anti-inflammatory activity.

Publication DOI: https://doi.org/10.4103/0975-9476.104427
Divisions: College of Health & Life Sciences > Aston Pharmacy School
College of Health & Life Sciences
College of Health & Life Sciences > School of Biosciences > Cell & Tissue Biomedical Research
Additional Information: Creative Commons Attribution Non-Commercial Share Alike License
Uncontrolled Keywords: Analgesic,anti-oxidative activity,antipyretic,Aquilaria crassna,rodents,Drug Discovery,Complementary and alternative medicine
Full Text Link: https://www.ncb ... /JAIM-3-175.pdf
Related URLs: http://www.scop ... tnerID=8YFLogxK (Scopus URL)
http://www.jaim ... last=Sattayasai (Publisher URL)
PURE Output Type: Article
Published Date: 2012-10
Authors: Sattayasai, Jintana
Bantadkit, Jirawat
Aromdee, Chantana
Lattmann, Eric
Airarat, Wanchai

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