Paediatric drug development of ramipril:reformulation, in vitro and in vivo evaluation


Ramipril is used mainly for the treatment of hypertension and to reduce incidence of fatality following heart attacks in patients who develop indications of congestive heart failure. In the paediatric population it is used most commonly for the treatment of heart failure, hypertension in type 1 diabetes and diabetic nephropathy. Due to the lack of a suitable liquid formulation, the current study evaluates the development of a range of oral liquid formulations of ramipril along with their in vitro and in vivo absorption studies. Three different formulation development approaches were studied: solubilisation using acetic acid as a co-solvent, complexation with hydroxypropyl-β-cyclodextrin (HP-β-CD) and suspension development using xanthan gum. Systematic optimisation of formulation parameters for the different strategies resulted in the development of products stable for twelve months at long term stability conditions. In vivo evaluation showed CMAX of 10.48 µg/mL for co-solvent, 13.04µg/ml for the suspension and 29.58µg/mL for the cyclodextrin based ramipril solution. Interestingly, both ramipril solution (co-solvent) and the suspension showed a TMAX of 2.5h, however, cyclodextrin based ramipril produced TMAX at 0.75h following administration. The results presented in this study provide translatable products for oral liquid ramipril which offer preferential paediatric use over existing alternatives.

Publication DOI:
Divisions: College of Health & Life Sciences > Aston Pharmacy School
College of Health & Life Sciences
College of Health & Life Sciences > Chronic and Communicable Conditions
Additional Information: This is an Accepted Manuscript of an article published by Taylor & Francis in Journal of Drug Targeting on 7/5/15, available online: Funding: BBSRC (BB/H016716/1).
Uncontrolled Keywords: Caco2,liquid formulation,oral drug delivery,ramipril,Pharmaceutical Science
Publication ISSN: 1029-2330
Last Modified: 19 Jun 2024 07:11
Date Deposited: 11 May 2015 10:25
Full Text Link: http://www.tand ... 6X.2015.1036275
Related URLs: http://www.scop ... tnerID=8YFLogxK (Scopus URL)
PURE Output Type: Article
Published Date: 2015
Published Online Date: 2015-05-07
Authors: Russell, Craig (ORCID Profile 0000-0003-3791-2161)
Begum, Sumyra
Hussain, Yasar
Hussain, Majad
Huen, David
Rahman, Ayesha S
Perrie, Yvonne
Mohammed, Afzal R. (ORCID Profile 0000-0002-5212-3040)



Version: Accepted Version

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