A pragmatic approach for engineering porous mannitol and mechanistic evaluation of particle performance

Abstract

The importance of mannitol has increased recently as an emerging diluent for orodispersible dosage forms. The study aims to prepare spray dried mannitol retaining high porosity and mechanical strength for the development of orally disintegrating tablets (ODTs). Aqueous feed of d-mannitol (10% w/v) comprising ammonium bicarbonate, NH4HCO3 (5% w/v) as pore former was spray dried at inlet temperature of 110-170°C. Compacts were prepared at 151MPa and characterized for porosity, hardness and disintegration time. Particle morphology and drying mechanisms were studied using thermal (HSM, DSC and TGA) and polymorphic (XRD) methods. Tablet porosity increased from 0.20±0.002 for pure mannitol to 0.53±0.03 using fabricated porous mannitol. Disintegration time dropped by 50-77% from 135±5.29s for pure mannitol to 75.33±2.52-31.67±1.53s for mannitol 110-170°C. Hardness increased by 150% at 110°C (258.67±28.89N) and 30% at 150°C (152.70±10.58N) compared to pure mannitol tablets (104.17±1.70N). Increasing inlet temperature resulted in reducing tablet hardness due to generation of 'micro-sponge'-like particles exhibiting significant elastic recovery. Impact of mannitol polymorphism on plasticity/elasticity cannot be ruled out as a mixture of α and β polymorphs formed upon spray drying.

Publication DOI: https://doi.org/10.1016/j.ejpb.2015.04.011
Divisions: College of Health & Life Sciences > Aston Pharmacy School
College of Health & Life Sciences
College of Health & Life Sciences > Chronic and Communicable Conditions
Additional Information: Copyright © 2015 Elsevier B.V. All rights reserved.
Uncontrolled Keywords: hardness,mannitol,orally disintegrating tablet,particle engineering,plasticity,porosity,spray drying,Biotechnology,Pharmaceutical Science
Publication ISSN: 1873-3441
Last Modified: 01 Oct 2024 07:20
Date Deposited: 11 May 2015 10:10
Full Text Link:
Related URLs: http://www.scop ... tnerID=8YFLogxK (Scopus URL)
PURE Output Type: Article
Published Date: 2015-05-07
Published Online Date: 2015-05-07
Authors: Al-Khattawi, Ali (ORCID Profile 0000-0002-2498-2817)
Koner, Jasdip
Rue, Peter
Kirby, Dan (ORCID Profile 0000-0002-0878-2620)
Perrie, Yvonne
Rajabi-Siahboomi, Ali
Mohammed, Afzal R. (ORCID Profile 0000-0002-5212-3040)

Export / Share Citation


Statistics

Additional statistics for this record