Bürkle, Alexander, Moreno-Villanueva, María, Bernhard, Jürgen, Blasco, María, Zondag, Gerben, Hoeijmakers, Jan H.J., Toussaint, Olivier, Grubeck-Loebenstein, Beatrix, Mocchegiani, Eugenio, Collino, Sebastiano, Gonos, Efstathios S., Sikora, Ewa, Gradinaru, Daniela, Dollé, Martijn, Salmon, Michel, Kristensen, Peter, Griffiths, Helen R., Libert, Claude, Grune, Tilman, Breusing, Nicolle, Simm, Andreas, Franceschi, Claudio, Capri, Miriam, Talbot, Duncan, Caiafa, Paola, Friguet, Bertrand, Slagboom, P. Eline, Hervonen, Antti, Hurme, Mikko and Aspinall, Richard (2015). MARK-AGE biomarkers of ageing. Mechanisms of Ageing and Development, 151 , pp. 2-12.
Abstract
Many candidate biomarkers of human ageing have been proposed in the scientific literature but in all cases their variability in cross-sectional studies is considerable, and therefore no single measurement has proven to serve a useful marker to determine, on its own, biological age. A plausible reason for this is the intrinsic multi-causal and multi-system nature of the ageing process. The recently completed MARK-AGE study was a large-scale integrated project supported by the European Commission. The major aim of this project was to conduct a population study comprising about 3200 subjects in order to identify a set of biomarkers of ageing which, as a combination of parameters with appropriate weighting, would measure biological age better than any marker in isolation.
| Publication DOI: | https://doi.org/10.1016/j.mad.2015.03.006 |
|---|---|
| Divisions: | College of Health & Life Sciences College of Health & Life Sciences > Chronic and Communicable Conditions College of Health & Life Sciences > School of Biosciences > Cell & Tissue Biomedical Research |
| Additional Information: | © 2015 Z. Published by Elsevier Ireland Ltd. This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/). European Commission for financial support through the FP7 large-scale integrating project “European Study to Establish Biomarkers of Human Ageing” (MARK-AGE; grant agreement no.: 200880. |
| Uncontrolled Keywords: | ageing biomarkers,human studies,MARK-AGE,Ageing,Developmental Biology |
| Publication ISSN: | 1872-6216 |
| Last Modified: | 12 Nov 2024 08:06 |
| Date Deposited: | 30 Apr 2015 11:15 |
| Full Text Link: | |
| Related URLs: |
http://www.scop ... tnerID=8YFLogxK
(Scopus URL) |
PURE Output Type: | Article |
| Published Date: | 2015-11 |
| Published Online Date: | 2015-03-24 |
| Authors: |
Bürkle, Alexander
Moreno-Villanueva, María Bernhard, Jürgen Blasco, María Zondag, Gerben Hoeijmakers, Jan H.J. Toussaint, Olivier Grubeck-Loebenstein, Beatrix Mocchegiani, Eugenio Collino, Sebastiano Gonos, Efstathios S. Sikora, Ewa Gradinaru, Daniela Dollé, Martijn Salmon, Michel Kristensen, Peter Griffiths, Helen R. ( 
0000-0002-2666-2147)
Libert, Claude Grune, Tilman Breusing, Nicolle Simm, Andreas Franceschi, Claudio Capri, Miriam Talbot, Duncan Caiafa, Paola Friguet, Bertrand Slagboom, P. Eline Hervonen, Antti Hurme, Mikko Aspinall, Richard |
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