Recent advances in topical therapeutics for vitreoretinal diseases

Abstract

Eye drops are convenient for patients, but achieving therapeutic doses and maintaining sustained drug release without frequent re-application to treat diseases of the retina has been largely unsuccessful. Topical administration of drugs is hindered by the anatomy, physiology, and biochemistry of the eye and its highly effective defence mechanisms. Advances in nanotechnology have led to the experimental use of topical permeation-enhancing liposomes, emulsions, and microspheres to enhance absorption and penetration of drugs across membranes; allow controlled release of the drug; and to target drugs at distinct tissues to allow sufficient local bioavailability. In the near future it is hoped that improved technologies may provide means of sustained topical drug delivery for retinal therapy, with improved side-effect profiles and reduced cost compared with currently available clinical treatments.

Divisions: College of Health & Life Sciences > School of Optometry > Optometry & Vision Science Research Group (OVSRG)
College of Health & Life Sciences
College of Health & Life Sciences > School of Optometry > Vision, Hearing and Language
College of Health & Life Sciences > School of Optometry > Optometry
Additional Information: This article is published under the Creative Commons Attribution Noncommercial License, which permits any noncommercial use, distribution, adaptation, and reproduction provided the original author(s) and source are given appropriate credit.
Uncontrolled Keywords: nanoparticles,eye drops,diabetes,retinal disorders,topical ocular delivery,liposomes,Medicine(all)
Publication ISSN: 1756-1795
Last Modified: 10 Jun 2024 07:12
Date Deposited: 16 Mar 2015 15:45
Full Text Link: http://www.touc ... etinal-diseases
Related URLs:
PURE Output Type: Article
Published Date: 2015
Authors: Gibson, Jonathan (ORCID Profile 0000-0002-9281-5244)
McGinnigle, Samantha

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License: Creative Commons Attribution Non-commercial


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