Gibson, Jonathan and McGinnigle, Samantha (2015). Recent advances in topical therapeutics for vitreoretinal diseases. US Ophthalmic Review, 8 (1), pp. 2-7.
Abstract
Eye drops are convenient for patients, but achieving therapeutic doses and maintaining sustained drug release without frequent re-application to treat diseases of the retina has been largely unsuccessful. Topical administration of drugs is hindered by the anatomy, physiology, and biochemistry of the eye and its highly effective defence mechanisms. Advances in nanotechnology have led to the experimental use of topical permeation-enhancing liposomes, emulsions, and microspheres to enhance absorption and penetration of drugs across membranes; allow controlled release of the drug; and to target drugs at distinct tissues to allow sufficient local bioavailability. In the near future it is hoped that improved technologies may provide means of sustained topical drug delivery for retinal therapy, with improved side-effect profiles and reduced cost compared with currently available clinical treatments.
Divisions: | College of Health & Life Sciences > School of Optometry > Optometry & Vision Science Research Group (OVSRG) College of Health & Life Sciences College of Health & Life Sciences > School of Optometry > Vision, Hearing and Language College of Health & Life Sciences > School of Optometry > Optometry |
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Additional Information: | This article is published under the Creative Commons Attribution Noncommercial License, which permits any noncommercial use, distribution, adaptation, and reproduction provided the original author(s) and source are given appropriate credit. |
Uncontrolled Keywords: | nanoparticles,eye drops,diabetes,retinal disorders,topical ocular delivery,liposomes,General Medicine |
Publication ISSN: | 1756-1795 |
Last Modified: | 01 Oct 2024 07:19 |
Date Deposited: | 16 Mar 2015 15:45 |
Full Text Link: |
http://www.touc ... etinal-diseases |
Related URLs: | PURE Output Type: | Article |
Published Date: | 2015 |
Authors: |
Gibson, Jonathan
(
0000-0002-9281-5244)
McGinnigle, Samantha |