Improving T cell-induced response to subunit vaccines:opportunities for a proteomic systems approach


Prophylactic vaccines are an effective strategy to prevent development of many infectious diseases. With new and re-emerging infections posing increasing risks to food stocks and the health of the population in general, there is a need to improve the rationale of vaccine development. One key challenge lies in development of an effective T cell-induced response to subunit vaccines at specific sites and in different populations. Objectives: In this review, we consider how a proteomic systems-based approach can be used to identify putative novel vaccine targets, may be adopted to characterise subunit vaccines and adjuvants fully. Key findings: Despite the extensive potential for proteomics to aid our understanding of subunit vaccine nature, little work has been reported on identifying MHC 1-binding peptides for subunit vaccines generating T cell responses in the literature to date. Summary: In combination with predictive and structural biology approaches to mapping antigen presentation, proteomics offers a powerful and as yet un-tapped addition to the armoury of vaccine discovery to predict T-cell subset responses and improve vaccine design strategies.

Publication DOI:
Divisions: College of Health & Life Sciences > School of Biosciences
College of Health & Life Sciences
College of Health & Life Sciences > Chronic and Communicable Conditions
College of Health & Life Sciences > School of Biosciences > Cell & Tissue Biomedical Research
Additional Information: This is the peer reviewed version of the following article: Dunston, CR, Herbert, R & Griffiths, HR 2015, 'Improving T cell-induced response to subunit vaccines: opportunities for a proteomic systems approach' Journal of pharmacy and pharmacology, vol 67, no. 3, pp. 290-299, which has been published in final form at This article may be used for non-commercial purposes in accordance With Wiley Terms and Conditions for self-archiving.
Uncontrolled Keywords: biotechnology and drug discovery,rational vaccine design,Pharmacology,Pharmaceutical Science
Publication ISSN: 2042-7158
Last Modified: 04 Mar 2024 08:13
Date Deposited: 16 Mar 2015 14:20
Full Text Link: http://onlineli ... .12383/abstract
Related URLs: http://www.scop ... tnerID=8YFLogxK (Scopus URL)
PURE Output Type: Article
Published Date: 2015
Published Online Date: 2015-02-23
Authors: Dunston, Christopher R.
Herbert, Rebecca
Griffiths, Helen R. (ORCID Profile 0000-0002-2666-2147)



Version: Accepted Version

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