The interconnectedness of ageing:does the convoy principal apply?


This is an excerpt from the content: The convoy principal states that any system is only as functional as its ‘slowest’ unit. As organisms are made up of interconnected networks of physiological systems, it is possible that this principle applies to the biology of ageing. Often biogerontology will focus either on organismal ageing (mechanisms associated with increased longevity of a lower model organism for example), ageing of an individual organ system (such as the cardiovascular/musculoskeletal/immune) or ageing at the cellular level (from telomere length to cellular senescence, with many different cell types being studied) without considering the interconnectedness between the three and importantly, between the separate units of the convoy; the different organ systems. Conceptually, research that aims to identify ‘anti-ageing’ therapies is often deemed to be reaching for a panacea that will arrest or slow down the ageing process as a whole, whereas a more realistic aim is to first identify how we can improve the perfor ...

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Divisions: College of Health & Life Sciences > School of Biosciences
College of Health & Life Sciences
College of Health & Life Sciences > Chronic and Communicable Conditions
College of Health & Life Sciences > School of Biosciences > Cell & Tissue Biomedical Research
Additional Information: The final publication is available at Springer via
Uncontrolled Keywords: Geriatrics and Gerontology,Gerontology,Ageing
Publication ISSN: 1573-6768
Last Modified: 27 Feb 2024 08:10
Date Deposited: 12 Mar 2015 15:25
Full Text Link: http://link.spr ... 0522-015-9556-1
Related URLs: http://www.scop ... tnerID=8YFLogxK (Scopus URL)
PURE Output Type: Article
Published Date: 2015-04
Published Online Date: 2015-02-04
Authors: Saffrey, Jill
Brown, James E. (ORCID Profile 0000-0002-3504-7373)



Version: Accepted Version

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