Modular construction of dynamic nucleodendrimers


Isoguanosine-containing dendritic small molecules self-assemble into decameric nucleodendrimers as observed by 1D NMR spectroscopy, 2D DOSY, and mass spectrometry. In particular, apolar building blocks readily form pentameric structures in acetonitrile while the presence of alkali metals promotes the formation of stable decameric assemblies with a preference for cesium ions. Remarkably, co-incubation of guanosine and isoguanosine-containing nucleodendrons results in the formation of decameric structures in absence of added salts. Further analysis of the mixture indicated that guanosine derivatives facilitate the formation, but are not involved in decameric structures; a process reminiscent of molecular crowding. This molecular system provides a powerful canvas for the rapid and modular assembly of polyfunctional dendritic macromolecules.

Publication DOI:
Divisions: College of Engineering & Physical Sciences > School of Infrastructure and Sustainable Engineering > Chemical Engineering & Applied Chemistry
Additional Information: © 2014 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim. This is the peer reviewed version of the article which has been published in final form at 10.1002/anie.201402400. This article may be used for non-commercial purposes in accordance with Wiley Terms and Conditions for Self-Archiving. Funding: Centre National de la Recherche Scientifique.
Uncontrolled Keywords: cesium,dendrimers,isoguanosine,NMR spectroscopy,self-assembly,Chemistry(all),Catalysis
Publication ISSN: 1521-3773
Full Text Link: http://onlineli ... 402400/abstract
Related URLs: http://www.scop ... tnerID=8YFLogxK (Scopus URL)
PURE Output Type: Article
Published Date: 2014-05-05
Published Online Date: 2014-04-02
Authors: Abet, Valentina
Evans, Robert (ORCID Profile 0000-0003-1471-201X)
Guibbal, Florian
Caldarelli, Stefano
Rodriguez, Raphaël



Version: Accepted Version

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