Effects of ball-milling on PLGA polymer and its implication on lansoprazole-loaded nanoparticles


PLGA is a biodegradable polymer utilised widely in pharmaceutical research for the encapsulation of a wide range of drugs as nano particulate systems. This study investigates the impact of rotary ball milling on the physical properties of PLGA and its influence on nanoparticle formation prepared using the solvent displacement technique. By applying mechanical stress to the polymer and altering its physical appearance and molecular weight, the loading of lansoprazole within the nanoparticles was increased to 96%, with a reduction in particle size. The results indicate that rotary ball milling significantly reduces particle size, increases lansoprazole loading and improves the release profile for lansoprazole loaded PLGA nanoparticles.

Divisions: College of Health & Life Sciences > Aston Pharmacy School
College of Health & Life Sciences
College of Health & Life Sciences > Chronic and Communicable Conditions
Additional Information: Creative Commons Non-commercial Share-alike
Publication ISSN: 0976-0113
Last Modified: 27 Jun 2024 08:24
Date Deposited: 06 Oct 2014 13:50
PURE Output Type: Article
Published Date: 2011-03
Authors: Shabir, Anjumn
Alhusban, Farhan
Perrie, Yvonne
Mohammed, Afzal R. (ORCID Profile 0000-0002-5212-3040)


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