In vitro bioactivity of titanium-doped bioglass


Previous studies have suggested that incorporating relatively small quantities of titanium dioxide into bioactive glasses may result in an increase in bioactivity and hydroxyapatite formation. The present work therefore investigated the in vitro bioactivity of a titanium doped bioglass and compared the results with 45S5 bioglass. Apatite formation was evaluated for bioglass and Ti-bioglass in the presence and absence of foetal calf serum. Scanning electron microscopy (SEM) images were used to evaluate the surface development and energy dispersive X-ray measurements provided information on the elemental ratios. X-ray diffraction spectra confirmed the presence of apatite formation. Cell viability was assessed for bone marrow stromal cells under direct and indirect contact conditions and cell adhesion was assessed using SEM.

Publication DOI:
Divisions: College of Engineering & Physical Sciences > School of Informatics and Digital Engineering > Electrical and Electronic Engineering
Additional Information: The final publication is available at Springer via
Uncontrolled Keywords: Biomaterials,Bioengineering,Biomedical Engineering,Biophysics
Full Text Link: http://link.spr ... 0856-014-5230-4
Related URLs: http://www.scop ... tnerID=8YFLogxK (Scopus URL)
PURE Output Type: Article
Published Date: 2014-08
Published Online Date: 2014-05-07
Authors: Asif, Imran M.
Shelton, Richard M.
Cooper, Paul R.
Addison, Owen
Martin, Richard A. (ORCID Profile 0000-0002-6013-2334)



Version: Accepted Version

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