Aluminium hydroxide stabilised MnFe2O4 and Fe3O4 nanoparticles as dual-modality contrasts agent for MRI and PET imaging


Magnetic nanoparticles (NPs) MnFe2O4 and Fe3O4 were stabilised by depositing an Al(OH)3 layer via a hydrolysis process. The particles displayed excellent colloidal stability in water and a high affinity to [18F]-fluoride and bisphosphonate groups. A high radiolabeling efficiency, 97% for 18F-fluoride and 100% for 64Cu-bisphosphonate conjugate, was achieved by simply incubating NPs with radioactivity solution at room temperature for 5min. The properties of particles were strongly dependant on the thickness and hardness of the Al(OH)3 layer which could in turn be controlled by the hydrolysis method. The application of these Al(OH)3 coated magnetic NPs in molecular imaging has been further explored. The results demonstrated that these NPs are potential candidates as dual modal probes for MR and PET. In vivo PET imaging showed a slow release of 18F from NPs, but no sign of efflux of 64Cu.

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Additional Information: Creative Commons Attribution 3.0 Unported (CC BY 3.0) Open Access funded by Wellcome Trust. Funding: Centre of Excellence in Medical Engineering funded by the Wellcome Trust; EPSRC under grant number WT088641/Z/09/Z and WT088641/Z/09/Z (in association with the MRC); King’s College London; UCL Comprehensive Cancer Imaging Centre funded by the CRUK (C1519/A10331); and National Institute for Health Research Biomedical Research Centre at Guy’s and St Thomas’ NHS Foundation Trust and King’ s College London. The scanning equipment funded by an equipment grant from the Wellcome Trust. Supplementary data: http://
Uncontrolled Keywords: magnetic nanoparticles,PET,aluminium hydroxide,dual-modal,18F
Publication ISSN: 1878-5905
Last Modified: 23 Feb 2024 08:07
Date Deposited: 19 Aug 2014 14:50
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Related URLs: http://www.scop ... tnerID=8YFLogxK (Scopus URL)
https://www.sci ... 3676?via%3Dihub (Publisher URL)
PURE Output Type: Article
Published Date: 2014-07-01
Published Online Date: 2014-04-24
Authors: Cui, Xianjin
Belo, Salome
Krüger, Dirk
Yan, Yong
de Rosales, Rafael T.M.
Jauregui-Osoro, Maite
Ye, Haitao (ORCID Profile 0000-0002-4005-4922)
Su, Shi
Mathe, Domokos
Kovács, Noémi
Horváth, Ildikó
Semjeni, Mariann
Sunassee, Kavitha
Szigeti, Krisztian
Green, Mark A.
Blower, Philip J.



Version: Published Version

License: Creative Commons Attribution

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