The role of lipid geometry in designing liposomes for the solubilisation of poorly water soluble drugs


Liposomes are well recognised for their ability to improve the delivery of a range of drugs. More commonly they are applied for the delivery of water-soluble drugs, but given their structural attributes, they can also be employed as solubilising agents for low solubility drugs as well as drug targeting agents. To further explore the potential of liposomes as solubilising agents, we have investigated the role of bilayer packaging in promoting drug solubilisation in liposome bilayers. The effect of alkyl chain length and symmetry was investigated to consider if using 'mis-matched' phospholipids could create 'voids' within the bilayers, and enhance bilayer loading capacity. Lipid packing was investigated using Langmuir studies, which demonstrated that increasing the alkyl chain length enhanced lipid packing, with condensed monolayers forming, whilst asymmetric lipids formed less condensed monolayers. However, this more open packing did not translate into improved drug loading, with the longer chain, condensed bilayers formed from long-chain, saturated lipids offering higher drug loading capacity. These studies demonstrate that liposomes formulated from longer chain, saturated lipids offer enhanced solubilisation capacity. However the molecular size, rather than lipophilicity, of the drug to be incorporated was also a key factor dominating bilayer incorporation efficiency. © 2012 Elsevier B.V. All rights reserved.

Publication DOI:
Divisions: College of Health & Life Sciences > Aston Pharmacy School
College of Health & Life Sciences
College of Health & Life Sciences > Chronic and Communicable Conditions
Additional Information: NOTICE: this is the author’s version of a work that was accepted for publication in Journal of Controlled Release. Changes resulting from the publishing process, such as peer review, editing, corrections, structural formatting, and other quality control mechanisms may not be reflected in this document. Changes may have been made to this work since it was submitted for publication. A definitive version was subsequently published in Ali, MH, Moghaddam, B, Kirby, DJ, Mohammed, AR & Perrie, Y, 'The role of lipid geometry in designing liposomes for the solubilisation of poorly water soluble drugs' International journal of pharmaceutics, vol 453, no. 1 (2012) DOI M. Habib Ali was funded the Engineering and Physical Sciences Research Council (Grant GR/S61287/01). Behfar Moghaddam was funded by an Aston University International Student Scholarship. Supplementary data available on the journal website.
Uncontrolled Keywords: liposomes,low soluble drugs,Bilayer drug loading,solubilisation,monolayer studies,Pharmaceutical Science
Publication ISSN: 1873-3476
Last Modified: 26 Feb 2024 08:12
Date Deposited: 19 Aug 2014 08:45
Full Text Link:
Related URLs: http://www.scop ... tnerID=8YFLogxK (Scopus URL)
PURE Output Type: Article
Published Date: 2013-08-30
Published Online Date: 2012-07-02
Authors: Ali, M. Habib
Moghaddam, Behfar
Kirby, Daniel J. (ORCID Profile 0000-0002-0878-2620)
Mohammed, Afzal R. (ORCID Profile 0000-0002-5212-3040)
Perrie, Yvonne



Version: Accepted Version

Export / Share Citation


Additional statistics for this record