Disturbing visual working memory:electrophysiological evidence for a role of the prefrontal cortex in recovery from interference


Single cell recordings in monkeys support the notion that the lateral prefrontal cortex (PFC) controls reactivation of visual working memory representations when rehearsal is disrupted. In contrast, recent fMRI findings yielded a double dissociation for PFC and the medial temporal lobe (MTL) in a letter working memory task. PFC was engaged in interference protection during reactivation while MTL was prominently involved in the retrieval of the letter representations. We present event-related potential data (ERP) that support PFC involvement in the top-down control of reactivation during a visual working memory task with endogenously triggered recovery after visual interference. A differentiating view is proposed for the role of PFC in working memory with respect to endogenous/exogenous control and to stimulus type. General implications for binding and retention mechanisms are discussed.

Publication DOI: https://doi.org/10.1093/cercor/bhh208
Divisions: College of Health & Life Sciences > School of Psychology
College of Health & Life Sciences > Clinical and Systems Neuroscience
College of Health & Life Sciences > School of Optometry > Centre for Vision and Hearing Research
Additional Information: This is a pre-copyedited, author-produced PDF of an article accepted for publication in Cerebral cortex following peer review. The definitive publisher-authenticated version [insert complete citation information here] is available online at: http://cercor.oxfordjournals.org/content/15/7/1075.abstract
Uncontrolled Keywords: prefrontal cortex,working memory,temporal lobe,endogenously triggered recovery,exogenous control,endogenous control
Publication ISSN: 1460-2199
Last Modified: 04 Jan 2024 08:18
Date Deposited: 15 Jul 2014 08:30
Full Text Link:
Related URLs: http://cercor.o ... 7/1075.abstract (Publisher URL)
PURE Output Type: Article
Published Date: 2005-07
Published Online Date: 2004-11-24
Authors: Kessler, Klaus (ORCID Profile 0000-0001-7307-9539)
Kiefer, Markus



Version: Accepted Version

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