Resveratrol and the eye:activity and molecular mechanisms


Purpose: Alcohol consumption is inversely correlated with the incidence of cardiovascular disease. It is thought that red wine is specifically responsible for these cardiovascular benefits, due to its ability to reduce vascular inflammation, facilitate vasorelaxation, and inhibit angiogenesis. This is because of its high polyphenolic content. Resveratrol is the main biologically active polyphenol within red wine. Owing to its vascular-enhancing properties, resveratrol may be effective in the microcirculation of the eye, thereby helping prevent ocular diseases such as age-related macular degeneration, diabetic retinopathy, and glaucoma. Such conditions are accountable for worldwide prevalence of visual loss. Method: A review of the relevant literature was conducted on the ScienceDirect, Web of Science, and PubMed databases. Key words used to carry out the searches included 'red wine', 'polyphenols', 'resveratrol', 'eye' and 'ocular'. Articles relating to the effects of resveratrol on the eye were reviewed. Results: The protective effects of resveratrol within the eye are extensive. It has been demonstrated to have anti-oxidant, anti-apoptotic, anti-tumourogenic, anti-inflammatory, anti-angiogenic and vasorelaxant properties. There are potential benefits of resveratrol supplementation across a wide range of ocular diseases. The molecular mechanisms underlying these protective actions are diverse. Conclusion: Evidence suggests that resveratrol may have potential in the treatment of several ocular diseases. However, while there are many studies indicating plausible biological mechanisms using animal models and in-vitro retinal cells there is a paucity of human research. The evidence base for the use of resveratrol in the management of ocular diseases needs to be increased before recommendations can be made for the use of resveratrol as an ocular supplement. © 2014 Springer-Verlag.

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Divisions: College of Health & Life Sciences > School of Optometry > Optometry
College of Health & Life Sciences > School of Optometry > Optometry & Vision Science Research Group (OVSRG)
College of Health & Life Sciences
College of Health & Life Sciences > School of Optometry > Vision, Hearing and Language
Uncontrolled Keywords: age-related macular degeneration,alcohol,diabetic retinopathy,polyphenols,red wine,resveratrol,retinopathy of prematurity,Ophthalmology,Sensory Systems,Cellular and Molecular Neuroscience
Publication ISSN: 1435-702X
Last Modified: 17 May 2024 07:10
Date Deposited: 10 Apr 2014 10:31
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Related URLs: http://www.scop ... tnerID=8YFLogxK (Scopus URL)
http://link.spr ... 0417-014-2604-8 (Publisher URL)
PURE Output Type: Review article
Published Date: 2014-03-21
Authors: Bola, Christina
Bartlett, Hannah (ORCID Profile 0000-0002-7531-6902)
Eperjesi, Frank (ORCID Profile 0000-0003-4358-0095)



Version: Accepted Version

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