Wood, M.J. (1988). Stability of Anthracycline Cytotoxic Agents in Solution and Infusion Fluids. Masters thesis, Aston University.
Abstract
Information on the stability of doxorubicin and daunorubicin is available in the literature but data are limited and contradictory. In addition few data have been published for epirubicin. The aim of this study was to more clearly, define the stability of these drugs in order to clarify the literature data. Reversed-phase, stability indicating HPLC assays were developed and used to investigate the effect of pH on the rate and mechanism of degradation by construction of a pH profile for each drug. Degradation kinetics were studied in fluorescent light and long term stability investigated in infusion fluids...
| Publication DOI: | https://doi.org/10.48780/publications.aston.ac.uk.00021925 |
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| Divisions: | College of Health & Life Sciences |
| Additional Information: | Copyright © M.J. Wood, 1988. M.J. Wood asserts their moral right to be identified as the author of this thesis. This copy of the thesis has been supplied on condition that anyone who consults it is understood to recognise that its copyright rests with its author and that no quotation from the thesis and no information derived from it may be published without appropriate permission or acknowledgement. If you have discovered material in Aston Publications Explorer which is unlawful e.g. breaches copyright, (either yours or that of a third party) or any other law, including but not limited to those relating to patent, trademark, confidentiality, data protection, obscenity, defamation, libel, then please read our Takedown Policy and contact the service immediately. |
| Institution: | Aston University |
| Uncontrolled Keywords: | anthracycline cytotoxic agents,infusion fluids |
| Last Modified: | 15 Apr 2025 13:45 |
| Date Deposited: | 27 Mar 2014 14:40 |
| Completed Date: | 1988-10 |
| Authors: |
Wood, M.J.
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