Plasma irisin levels predict telomere length in healthy adults


The ageing process is strongly influenced by nutrient balance, such that modest calorie restriction (CR) extends lifespan in mammals. Irisin, a newly described hormone released from skeletal muscles after exercise, may induce CR-like effects by increasing adipose tissue energy expenditure. Using telomere length as a marker of ageing, this study investigates associations between body composition, plasma irisin levels and peripheral blood mononuclear cell telomere length in healthy, non-obese individuals. Segmental body composition (by bioimpedance), telomere length and plasma irisin levels were assessed in 81 healthy individuals (age 43∈±∈15.8 years, BMI 24.3∈±∈2.9 kg/m2). Data showed significant correlations between log-transformed relative telomere length and the following: age (p∈<∈0.001), height (p∈=∈0.045), total body fat percentage (p∈=∈0.031), abdominal fat percentage (p∈=∈0.038) , visceral fat level (p∈<∈0.001), plasma leptin (p∈=∈0.029) and plasma irisin (p∈=∈0.011), respectively. Multiple regression analysis using backward elimination revealed that relative telomere length can be predicted by age (b∈=∈-0.00735, p∈=∈0.001) and plasma irisin levels (b∈=∈0.04527, p∈=∈0.021). These data support the view that irisin may have a role in the modulation of both energy balance and the ageing process. © 2014 The Author(s).

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Divisions: College of Health & Life Sciences > School of Biosciences
College of Health & Life Sciences > Chronic and Communicable Conditions
College of Health & Life Sciences
College of Health & Life Sciences > Clinical and Systems Neuroscience
College of Health & Life Sciences > School of Biosciences > Cell & Tissue Biomedical Research
Additional Information: Creative Commons Attribution (CC BY 4.0) license. The CC BY license permits commercial and non-commercial re-use of an open access article, as long as the original author and source are properly attributed.
Uncontrolled Keywords: adipose tissue,ageing,body composition,irisin,muscle,telomere length,Ageing,Geriatrics and Gerontology
Publication ISSN: 1574-4647
Last Modified: 07 Jun 2024 07:11
Date Deposited: 26 Feb 2014 03:14
Full Text Link: http://link.spr ... 1357-014-9620-9
Related URLs: http://www.scop ... tnerID=8YFLogxK (Scopus URL)
PURE Output Type: Article
Published Date: 2014-04
Published Online Date: 2014-01-29
Authors: Rana, Karan S.
Arif, Muhammad
Hill, Eric J. (ORCID Profile 0000-0002-9419-1500)
Aldred, Sarah
Nagel, David A. (ORCID Profile 0000-0002-9055-1775)
Nevill, Alan
Randeva, Harpal S.
Bailey, Clifford J. (ORCID Profile 0000-0002-6998-6811)
Bellary, Srikanth (ORCID Profile 0000-0002-5924-5278)
Brown, James E. (ORCID Profile 0000-0002-3504-7373)



Version: Published Version

License: Creative Commons Attribution

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