NADPH oxidase signaling and cardiac myocyte function


The NADPH oxidase family of enzymes has emerged as a major source of reactive oxygen species (ROS) that is important in diverse cellular functions including anti-microbial defence, inflammation and redox signaling. Of the five known NADPH oxidase isoforms, several are expressed in cardiovascular cells where they are involved in physiological and pathological processes such as the regulation of vascular tone, cell growth, migration, proliferation, hypertrophy, apoptosis and matrix deposition. This article reviews current knowledge regarding the role of NADPH oxidases in cardiomyocyte function in health and disease.

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Divisions: College of Health & Life Sciences > School of Biosciences
College of Health & Life Sciences > Aston Medical School
Additional Information: NOTICE: this is the author’s version of a work that was accepted for publication in Journal of molecular and cellular cardiology. Changes resulting from the publishing process, such as peer review, editing, corrections, structural formatting, and other quality control mechanisms may not be reflected in this document. Changes may have been made to this work since it was submitted for publication. A definitive version was subsequently published in Akki, A, Zhang, M, Murdoch, C, Brewer, A & Shah, AM, 'NADPH oxidase signaling and cardiac myocyte function' Journal of molecular and cellular cardiology, vol. 47, no. 1 (2009) DOI
Uncontrolled Keywords: NADPH oxidase,Redox,remodeling,hypertrophy,contraction,signaling,cardiac myocytes
Publication ISSN: 1095-8584
Last Modified: 27 Jun 2024 08:17
Date Deposited: 11 Feb 2014 09:42
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Related URLs: http://www.scop ... tnerID=8YFLogxK (Scopus URL)
PURE Output Type: Book/Film/Article review
Published Date: 2009-07
Authors: Akki, Ashwin
Zhang, Min
Murdoch, Colin (ORCID Profile 0000-0002-0274-819X)
Brewer, Alison
Shah, Ajay M.



Version: Accepted Version

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