Joining S100 proteins and migration:for better or for worse, in sickness and in health


The vast diversity of S100 proteins has demonstrated a multitude of biological correlations with cell growth, cell differentiation and cell survival in numerous physiological and pathological conditions in all cells of the body. This review summarises some of the reported regulatory functions of S100 proteins (namely S100A1, S100A2, S100A4, S100A6, S100A7, S100A8/S100A9, S100A10, S100A11, S100A12, S100B and S100P) on cellular migration and invasion, established in both culture and animal model systems and the possible mechanisms that have been proposed to be responsible. These mechanisms involve intracellular events and components of the cytoskeletal organisation (actin/myosin filaments, intermediate filaments and microtubules) as well as extracellular signalling at different cell surface receptors (RAGE and integrins). Finally, we shall attempt to demonstrate how aberrant expression of the S100 proteins may lead to pathological events and human disorders and furthermore provide a rationale to possibly explain why the expression of some of the S100 proteins (mainly S100A4 and S100P) has led to conflicting results on motility, depending on the cells used. © 2013 Springer Basel.

Publication DOI:
Divisions: College of Health & Life Sciences > School of Biosciences
College of Health & Life Sciences
College of Health & Life Sciences > School of Biosciences > Cellular and Molecular Biomedicine
Additional Information: The final publication is available at
Uncontrolled Keywords: cancer,cytoskeleton,invasion,migration/motility,receptor,S100 proteins,Cell Biology,Molecular Biology,Molecular Medicine,Pharmacology,Cellular and Molecular Neuroscience
Publication ISSN: 1420-9071
Last Modified: 05 Jul 2024 07:04
Date Deposited: 03 Feb 2014 14:27
Full Text Link: http://link.spr ... 0018-013-1400-7
Related URLs: http://www.scop ... tnerID=8YFLogxK (Scopus URL)
PURE Output Type: Review article
Published Date: 2014-05
Published Online Date: 2013-06-30
Authors: Gross, Stephane R. (ORCID Profile 0000-0002-0867-8866)
Sin, Connie G.T.
Barraclough, Roger
Rudland, Philip S.



Version: Accepted Version

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