Solid phase synthesis of a metronidazole oligonucleotide conjugate

Abstract

Direct, solid phase synthesis of an oligonucleotide conjugate of the antibiotic drug metronidazole was accomplished by the phosphoramidite method. Removal of protecting groups and cleavage from the controlled pore glass (CPG) solid support was successful using mild conditions (20% EtN in pyridine, then conc. NH (aq) at rt for 30 min) whereas standard conditions (conc. NH (aq) at 55°C for 16 h) cleaved the drug.

Publication DOI: https://doi.org/10.3390/11060486
Divisions: College of Health & Life Sciences > Aston Pharmacy School
College of Health & Life Sciences
Additional Information: Creative commons : Attribution
Uncontrolled Keywords: CPG,conjugate,metronidazole,oligonucleotide,phosphoramidite,solid phase
Publication ISSN: 1420-3049
Full Text Link:
Related URLs: http://www.scop ... tnerID=8YFLogxK (Scopus URL)
http://www.mdpi ... 0-3049/11/6/486 (Publisher URL)
PURE Output Type: Article
Published Date: 2006-06-23
Authors: Walsh, Andrew J.
Davis, Michael L.
Fraser, William (ORCID Profile 0000-0001-6588-0166)

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License: Creative Commons Attribution


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