Solid phase synthesis of a metronidazole oligonucleotide conjugate


Direct, solid phase synthesis of an oligonucleotide conjugate of the antibiotic drug metronidazole was accomplished by the phosphoramidite method. Removal of protecting groups and cleavage from the controlled pore glass (CPG) solid support was successful using mild conditions (20% EtN in pyridine, then conc. NH (aq) at rt for 30 min) whereas standard conditions (conc. NH (aq) at 55°C for 16 h) cleaved the drug.

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Divisions: College of Health & Life Sciences > Aston Pharmacy School
College of Health & Life Sciences
Additional Information: Creative commons : Attribution
Uncontrolled Keywords: CPG,conjugate,metronidazole,oligonucleotide,phosphoramidite,solid phase
Publication ISSN: 1420-3049
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Related URLs: http://www.scop ... tnerID=8YFLogxK (Scopus URL)
http://www.mdpi ... 0-3049/11/6/486 (Publisher URL)
PURE Output Type: Article
Published Date: 2006-06-23
Authors: Walsh, Andrew J.
Davis, Michael L.
Fraser, William (ORCID Profile 0000-0001-6588-0166)



Version: Published Version

License: Creative Commons Attribution

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