Investigation of formulation and process of lyophilised orally disintegrating tablet (ODT) using novel amino acid combination


Lyophilised orally disintegrating tablets (ODTs) have achieved a great success in overcoming dysphagia associated with conventional solid dosage forms. However, the extensive use of saccharides within the formulation limits their use in treatment of chronic illnesses. The current study demonstrates the feasibility of using combination of proline and serine to formulate zero sacharide ODTs and investigates the effect of freezing protocol on sublimation rate and tablets characteristics. The results showed that inclusion of proline and serine improved ODT properties when compared to individual counterparts. Additionally, annealing the ODTs facilitated the sublimation process and shortened the disintegration time.

Publication DOI:
Divisions: College of Health & Life Sciences > Aston Pharmacy School
College of Health & Life Sciences
College of Health & Life Sciences > Chronic and Communicable Conditions
Uncontrolled Keywords: annealing,lyophilisation,orally disintegrating tablets,proline,serine,sublimation rate,Pharmaceutical Science
Publication ISSN: 1999-4923
Last Modified: 25 Jan 2024 08:14
Date Deposited: 10 Oct 2013 09:54
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Related URLs: http://www.scop ... tnerID=8YFLogxK (Scopus URL)
PURE Output Type: Article
Published Date: 2010-01-04
Authors: AlHusban, Farhan
Elshaer, Amr M.
Kansara, Jiteen H.
Smith, Alan M.
Grover, Liam M.
Perrie, Yvonne
Mohammed, Afzal-Ur-Rahman (ORCID Profile 0000-0002-5212-3040)



Version: Published Version

License: Creative Commons Attribution

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