Preparation of 9-substituted pyridine-stretched adenines and hypoxanthines


9-Methylsulfanyl pyridine-stretched adenine and hypoxanthine derivatives have been prepared via regioselective reaction of a 5-aminoimidazole with 2-(bis-methylsulfanylmethylene)malononitrile [(NC)C=C(SMe) ]. The 9-methylsulfanyl substituent can be replaced by sequential oxidation and substitution by nucleophiles including amines.

Publication DOI:
Divisions: College of Health & Life Sciences > Aston Pharmacy School
College of Health & Life Sciences
Additional Information: © Georg Thieme Verlag Stuttgart - New York
Uncontrolled Keywords: 5-aminoimidazoles,lin-pyridoadenines,soft electrophiles,tricyclic heterocycles,pyridine-stretched purines
Publication ISSN: 1437-210X
Full Text Link: https://www.thi ... /s-0028-1088028
Related URLs: http://www.scop ... tnerID=8YFLogxK (Scopus URL)
PURE Output Type: Article
Published Date: 2009-04
Authors: Crawford, Julia A.
Fraser, William (ORCID Profile 0000-0001-6588-0166)
Ramsden, Christopher A.



Version: Accepted Version


Version: Draft Version

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