Crawford, Julia A., Fraser, William and Ramsden, Christopher A. (2009). Preparation of 9-substituted pyridine-stretched adenines and hypoxanthines. Synthesis, 2009 (8), pp. 1271-1278.
Abstract
9-Methylsulfanyl pyridine-stretched adenine and hypoxanthine derivatives have been prepared via regioselective reaction of a 5-aminoimidazole with 2-(bis-methylsulfanylmethylene)malononitrile [(NC)C=C(SMe) ]. The 9-methylsulfanyl substituent can be replaced by sequential oxidation and substitution by nucleophiles including amines.
| Publication DOI: | https://doi.org/10.1055/s-0028-1088028 |
|---|---|
| Divisions: | College of Health & Life Sciences > Aston Pharmacy School College of Health & Life Sciences |
| Additional Information: | © Georg Thieme Verlag Stuttgart - New York |
| Uncontrolled Keywords: | 5-aminoimidazoles,lin-pyridoadenines,soft electrophiles,tricyclic heterocycles,pyridine-stretched purines |
| Publication ISSN: | 1437-210X |
| Last Modified: | 14 Aug 2025 07:14 |
| Date Deposited: | 12 Jun 2013 08:57 |
| Full Text Link: |
https://www.thi ... /s-0028-1088028 |
| Related URLs: |
http://www.scop ... tnerID=8YFLogxK
(Scopus URL) |
PURE Output Type: | Article |
| Published Date: | 2009-04 |
| Authors: |
Crawford, Julia A.
Fraser, William ( 
0000-0001-6588-0166)
Ramsden, Christopher A. |
![[img]](https://publications.aston.ac.uk/style/images/fileicons/application_pdf.png)