Structural characterisation of hypoxia-mimicking bioactive glasses


Nickel and cobalt are both known to stimulate the hypoxia-inducible factor-1 (HIF-1a), thus significantly improving blood vessel formation in tissue engineering applications. We have manufactured nickel and cobalt doped bioactive glasses to act as a controlled delivery mechanism of these ions. The resultant structural consequences have been investigated using the methods of isotopic and isomorphic substitution applied to neutron diffraction. The structural sites present will be intimately related to their release properties in physiological fluids such as plasma and saliva, and hence the bioactivity of the material. Detailed structural knowledge is therefore a prerequisite for optimising material design. Results show that nickel and cobalt adopt a mixed structural role within these bioactive glasses occupying both network-forming (tetrahedral) and network-modifying (5-fold) geometries. Two thirds of the Ni (or Co) occupies a five-fold geometry with the remaining third in a tetrahedral environment. A direct comparison of the primary structural correlations (e.g. Si-O, Ca-O, Na-O and O-Si-O) between the archetypal 45S5 Bioglass® and the Ni and Co glasses studied here reveal no significant differences. This indicates that the addition of Ni (or Co) will have no adverse effects on the existing structure, and thus on in vitro/in vivo dissolution rates and therefore bioactivity of these glasses.

Publication DOI:
Divisions: College of Health & Life Sciences > School of Biosciences
Additional Information: The PDF may not further make it available or distribute it. Funding: EPSRC Project [EP/F021011/1]; STFC
Uncontrolled Keywords: bioglass,nickel,hypoxia,structure,neutron diffraction,isotopic substitution
Publication ISSN: 2050-750X
Full Text Link: http://pubs.rsc ... 3/tb/c3tb00408b
Related URLs: http://www.scop ... tnerID=8YFLogxK (Scopus URL)
PURE Output Type: Article
Published Date: 2013-03-07
Published Online Date: 2013-01-10
Authors: Smith, Jodie M.
Martin, Richard A. (ORCID Profile 0000-0002-6013-2334)
Cuello, Gabriel J.
Newport, Robert J.



Version: Accepted Version

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