Hendry, Emma, Conway, Barbara and Worthington, Tony (2012). Digluconate and isopropyl alcohol biocide formulation. International Journal of Molecular Sciences, 13 (11), pp. 14016-14025.
Abstract
Effective surface disinfection is a fundamental infection control strategy within healthcare. This study assessed the antimicrobial efficacy of novel biocide formulations comprising 5% and 2% eucalyptus oil (EO) combined with 2% chlorhexidine digluconate (CHG) and 70% isopropyl alcohol (IPA) contained within a wipe. The efficacy of this novel antimicrobial formulation to remove and eliminate methicillin-resistant Staphylococcus aureus (MRSA), Escherichia coli and Candida albicans from steel surfaces was investigated. Adpression studies of pre-contaminated wipes were also utilised to assess their potential to induce cross-contamination between hard surfaces. Furthermore, the bactericidal nature of the EO-formulation was established in addition to time-kill. The EO-containing formulations demonstrated bactericidal antimicrobial efficacy against all microorganisms and did not induce surface cross-contamination. There was no significant difference (p < 0.05) between the 5% and 2% EO formulations in their ability to remove microorganisms from steel surfaces, however both significantly (p < 0.05) removed more than the control formulations. Microbial biofilms were eliminated within 10 min (p < 0.05) when exposed to the EO formulations. Our novel EO-formulation demonstrated rapid antimicrobial efficacy for potential disinfection and elimination of microbial biofilms from hard surfaces and may therefore be a useful adjunct to current infection control strategies currently employed within healthcare facilities.
Publication DOI: | https://doi.org/10.3390/ijms131114016 |
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Divisions: | College of Health & Life Sciences College of Health & Life Sciences > School of Biosciences College of Health & Life Sciences > Chronic and Communicable Conditions Aston University (General) |
Additional Information: | Creative Commons Attribution License |
Uncontrolled Keywords: | eucalyptus oil,green biocide,biofilm,surface disinfection,chlorhexidine digluconate,healthcare associated infection,Computer Science Applications,Molecular Biology,Catalysis,Inorganic Chemistry,Spectroscopy,Organic Chemistry,Physical and Theoretical Chemistry |
Publication ISSN: | 1422-0067 |
Last Modified: | 02 Dec 2024 08:10 |
Date Deposited: | 20 May 2013 09:18 |
Full Text Link: |
http://www.mdpi ... 067/13/11/14016 |
Related URLs: |
http://www.scop ... tnerID=8YFLogxK
(Scopus URL) |
PURE Output Type: | Article |
Published Date: | 2012-10-30 |
Authors: |
Hendry, Emma
Conway, Barbara Worthington, Tony ( 0000-0002-1906-3357) |