Hipkiss, Alan R., Cartwright, Stephanie P., Bromley, Clare, Gross, Stephane R. and Bill, Roslyn M. (2013). Carnosine:can understanding its actions on energy metabolism and protein homeostasis inform its therapeutic potential? Chemistry Central Journal, 7 (1),
Abstract
The dipeptide carnosine (β-alanyl-L-histidine) has contrasting but beneficial effects on cellular activity. It delays cellular senescence and rejuvenates cultured senescent mammalian cells. However, it also inhibits the growth of cultured tumour cells. Based on studies in several organisms, we speculate that carnosine exerts these apparently opposing actions by affecting energy metabolism and/or protein homeostasis (proteostasis). Specific effects on energy metabolism include the dipeptide's influence on cellular ATP concentrations. Carnosine's ability to reduce the formation of altered proteins (typically adducts of methylglyoxal) and enhance proteolysis of aberrant polypeptides is indicative of its influence on proteostasis. Furthermore these dual actions might provide a rationale for the use of carnosine in the treatment or prevention of diverse age-related conditions where energy metabolism or proteostasis are compromised. These include cancer, Alzheimer's disease, Parkinson's disease and the complications of type-2 diabetes (nephropathy, cataracts, stroke and pain), which might all benefit from knowledge of carnosine's mode of action on human cells. © 2013 Hipkiss et al.; licensee Chemistry Central Ltd.
Publication DOI: | https://doi.org/10.1186/1752-153X-7-38 |
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Divisions: | College of Health & Life Sciences > School of Biosciences College of Health & Life Sciences College of Health & Life Sciences > School of Biosciences > Cellular and Molecular Biomedicine Aston University (General) |
Additional Information: | © 2013 Hipkiss et al.; licensee Chemistry Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
Uncontrolled Keywords: | carnosine,energy metabolism,reactive oxygen species,methylglyoxal,proteolysis,Alzheimer’s disease,Parkinson’s disease,diabetes,cancer,yeast,General Chemistry |
Publication ISSN: | 1752-153X |
Last Modified: | 14 Oct 2024 13:21 |
Date Deposited: | 29 Apr 2013 13:42 |
Full Text Link: |
http://journal. ... /content/7/1/38 |
Related URLs: |
http://www.scop ... tnerID=8YFLogxK
(Scopus URL) |
PURE Output Type: | Article |
Published Date: | 2013-02-25 |
Authors: |
Hipkiss, Alan R.
Cartwright, Stephanie P. Bromley, Clare Gross, Stephane R. ( 0000-0002-0867-8866) Bill, Roslyn M. ( 0000-0003-1331-0852) |