Brain mechanisms of altered consciousness in generalised seizures

Abstract

In spite of the inherent difficulties in achieving a biologically meaningful definition of consciousness, recent neurophysiological studies are starting to provide some insight in fundamental mechanisms associated with impaired consciousness in neurological disorders. Generalised seizures are associated with disruption of the default state network, a functional network of discrete brain areas, which include the fronto-parietal cortices. Subcortical contribution through activation of thalamocortical structures, as well as striate nuclei are also crucial to produce impaired consciousness in generalised seizures.

Publication DOI: https://doi.org/10.3233/BEN-2011-0317
Divisions: College of Health & Life Sciences > School of Psychology
College of Health & Life Sciences > Clinical and Systems Neuroscience
College of Health & Life Sciences > Aston Institute of Health & Neurodevelopment (AIHN)
College of Health & Life Sciences
Additional Information: © 2011 Hindawi Publishing Corporation and the authors. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
Uncontrolled Keywords: consciousness,generalized epilepsy,functional imaging,Clinical Neurology,Neurology,Neuropsychology and Physiological Psychology
Full Text Link:
Related URLs: http://www.scop ... tnerID=8YFLogxK (Scopus URL)
https://www.hin ... 011/491957/abs/ (Publisher URL)
PURE Output Type: Article
Published Date: 2011
Published Online Date: 2011-03-31
Authors: Seri, Stefano (ORCID Profile 0000-0002-9247-8102)
Brazzo, Daniela
Thai-Goodson, Ngoc
Cerquiglini, Antonella

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