Actin binding proteins:their ups and downs in metastatic life


In order to metastasize away from the primary tumor site and migrate into adjacent tissues, cancer cells will stimulate cellular motility through the regulation of their cytoskeletal structures. Through the coordinated polymerization of actin filaments, these cells will control the geometry of distinct structures, namely lamella, lamellipodia and filopodia, as well as the more recently characterized invadopodia. Because actin binding proteins play fundamental functions in regulating the dynamics of actin polymerization, they have been at the forefront of cancer research. This review focuses on a subset of actin binding proteins involved in the regulation of these cellular structures and protrusions, and presents some general principles summarizing how these proteins may remodel the structure of actin. The main body of this review aims to provide new insights into how the expression of these actin binding proteins is regulated during carcinogenesis and highlights new mechanisms that may be initiated by the metastatic cells to induce aberrant expression of such proteins. © 2013 Landes Bioscience.

Publication DOI:
Divisions: College of Health & Life Sciences > School of Biosciences
College of Health & Life Sciences
College of Health & Life Sciences > School of Biosciences > Cellular and Molecular Biomedicine
Additional Information: The journal of Cell adhesion and migration is the original source.
Uncontrolled Keywords: actin,arp2/3,cancer,fascin,miRNAs,tropomyosin,WASP,ZBP1,Cell Biology,Cellular and Molecular Neuroscience
Publication ISSN: 1933-6926
Last Modified: 18 Jun 2024 07:10
Date Deposited: 24 Jan 2013 12:42
Full Text Link: ... /article/23176/
Related URLs: http://www.scop ... tnerID=8YFLogxK (Scopus URL)
PURE Output Type: Article
Published Date: 2013-03
Authors: Gross, Stephane R. (ORCID Profile 0000-0002-0867-8866)



Version: Accepted Version

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