The ageing pancreas


Type 2 diabetes is historically associated with older adults, and glucose tolerance is known to decline with advancing age. During the course of natural ageing, changes in many peripheral tissues contribute to this deterioration of glucose homeostasis. Included in this process are changes to the structure and function of the pancreatic islets, which undergo deviation in endocrine responses to glycaemic challenge. Current knowledge about the changes seen in the ageing pancreas is reviewed here.

Publication DOI:
Divisions: College of Health & Life Sciences > School of Biosciences
College of Health & Life Sciences
College of Health & Life Sciences > Chronic and Communicable Conditions
Additional Information: Copyright 2012 Elsevier B.V., All rights reserved.
Uncontrolled Keywords: ageing,pancreatic islets ,β-cells
Publication ISSN: 1753-4305
Last Modified: 06 Feb 2024 08:04
Date Deposited: 04 Dec 2012 11:24
Full Text Link: http://dvd.sage ... ontent/12/3/141
Related URLs: http://www.scop ... tnerID=8YFLogxK (Scopus URL)
PURE Output Type: Article
Published Date: 2012-05
Authors: Brown, James E. (ORCID Profile 0000-0002-3504-7373)



Version: Draft Version

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